Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001150
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Induction of Suction Blisters in Patients With Urticaria Blistering Diseases Inflammatory Dermatoses and Neoplastic Disorders and in Normal Volunteers
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Induction of Suction Blisters in Patients With Urticaria Blistering Diseases Inflammatory Dermatoses and Neoplastic Disorders and in Normal Volunteers
Status:
COMPLETED
Status Verified Date:
2004-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells We have been able to prepare purified populations of these cells after blister formation Specifically using the blister tops we are able to enrich for epidermal Langerhans cells which are very potent stimulators in antigen presenting assays Thus this normal volunteer study provides an important source of fresh epidermal tissue from which we can study normal epidermal Langerhans cell function In addition we have recently used blister roofs in important experimental models of HIV-1 transmission There is no other method available for assessing the biologic function of freshly isolated Langerhans cells without altering their milieu It is a very safe and effective way to obtain human epidermal samples
Detailed Description:
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells We have been able to prepare purified populations of these cells after blister formation Specifically using the blister tops we are able to enrich for epidermal Langerhans cells which are very potent stimulators in antigen presenting assays Thus this normal volunteer study provides an important source of fresh epidermal tissue from which we can study normal epidermal Langerhans cell function In addition we have recently used blister roofs in important experimental models of HIV-1 transmission There is no other method available for assessing the biologic function of freshly isolated Langerhans cells without altering their milieu It is a very safe and effective way to obtain human epidermal samples
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 76-C-0293 | None | None | None |