Ignite Creation Date:
2024-05-05 @ 7:36 PM
Last Modification Date:
2024-10-26 @ 9:51 AM
Study NCT ID:
NCT00701051
Status:
COMPLETED
Last Update Posted:
2015-04-06
First Post:
2008-06-18
Brief Title:
Exercise Training and Glucose Metabolism in Aging
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Aging Angiogenesis and Metabolic Responses to Aerobic Exercise
Status:
COMPLETED
Status Verified Date:
2015-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Diabetes and its associated complications affect more than 20 million Americans and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40 of Americans over age 60 are affected In older adults glucose metabolism may be affected by reduced skeletal muscle capillary supply which limits insulin glucose and oxygen delivery to skeletal muscle Reduced capillary supply to skeletal muscle is found in older individuals with impaired glucose tolerance and we hypothesize that this is due to reduced vascular growth factor expression and chronic inflammation Further we hypothesize that reversal of a sedentary lifestyle through aerobic exercise training will increase insulin signaling and vascular growth factor expression as well as decrease inflammation to increase capillary supply to skeletal muscle which contributes to improved glucose metabolism in older adults This study will 1 Determine the mechanisms underlying reduced skeletal muscle capillarization in older adults with impaired glucose tolerance and 2 Determine the effect of aerobic exercise training-induced increases in skeletal muscle capillarization on glucose metabolism in older adults
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| H-27940 | OTHER | None | None |
| 5P30AG028747-05 | NIH | IRB | httpsreporternihgovquickSearch5P30AG028747-05 |