Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005366
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Biobehavioral Mechanisms of Blood Pressure Regulation
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the role of biobehavioral factors in the pathogenesis of concentric left ventricular hypertrophy
Detailed Description:
BACKGROUND
Hypertension is more prevalent in Black than white men and is more prevalent in men than women Furthermore even controlling for blood pressure concentric left ventricular hypertrophy an early structural adaptation of hypertension is more prevalent in Black than white men and more prevalent in men than women Concentric left ventricular hypertrophy is the strongest predictor other than age of the cardiovascular morbidity associated with high blood pressure
DESIGN NARRATIVE
In a biracial sample concentric left ventricular hypertrophy and concentric remodelling were assessed by echocardiographic measures of left ventricular mass and relative wall thickness Laboratory procedures were used to i assess hemodynamic and neurohumoral responses during exposure to a diverse battery of physical and psychological stressors and ii evaluate alpha and beta adrenergic receptor responsiveness baroreceptor reflex gain and minimal forearm vascular resistance Since blood pressure during a typical workday was an established predictor of left ventricular hypertrophy it was also assessed A new biobehavioral model was tested that implicated the hemodynamic pattern of behaviorally-evoked pressor responses in the pathogenesis of concentric left ventricular hypertrophy One prediction of this model was that a predisposition to exhibit increased vascular resistance during stress characteristic of black men would favor the development of concentric hypertrophy Thus systemic vascular resistance responses evaluated in the laboratory were hypothesized to independently predict left ventricular mass and relative wall thickness even after controlling for established risk factors including workday blood pressure Sympathetic nervous system function was examined to test hypothesized mechanisms responsible for race and gender differences in the hemodynamic patterns of blood pressure regulation The results of these studies emphasized the importance of race and gender in prescribing pharmacological andor behavioral treatment for hypertensive heart disease
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Hypertension is more prevalent in Black than white men and is more prevalent in men than women Furthermore even controlling for blood pressure concentric left ventricular hypertrophy an early structural adaptation of hypertension is more prevalent in Black than white men and more prevalent in men than women Concentric left ventricular hypertrophy is the strongest predictor other than age of the cardiovascular morbidity associated with high blood pressure
DESIGN NARRATIVE
In a biracial sample concentric left ventricular hypertrophy and concentric remodelling were assessed by echocardiographic measures of left ventricular mass and relative wall thickness Laboratory procedures were used to i assess hemodynamic and neurohumoral responses during exposure to a diverse battery of physical and psychological stressors and ii evaluate alpha and beta adrenergic receptor responsiveness baroreceptor reflex gain and minimal forearm vascular resistance Since blood pressure during a typical workday was an established predictor of left ventricular hypertrophy it was also assessed A new biobehavioral model was tested that implicated the hemodynamic pattern of behaviorally-evoked pressor responses in the pathogenesis of concentric left ventricular hypertrophy One prediction of this model was that a predisposition to exhibit increased vascular resistance during stress characteristic of black men would favor the development of concentric hypertrophy Thus systemic vascular resistance responses evaluated in the laboratory were hypothesized to independently predict left ventricular mass and relative wall thickness even after controlling for established risk factors including workday blood pressure Sympathetic nervous system function was examined to test hypothesized mechanisms responsible for race and gender differences in the hemodynamic patterns of blood pressure regulation The results of these studies emphasized the importance of race and gender in prescribing pharmacological andor behavioral treatment for hypertensive heart disease
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL049427 | NIH | None | httpsreporternihgovquickSearchR01HL049427 |