Ignite Creation Date:
2024-05-05 @ 7:29 PM
Last Modification Date:
2024-10-26 @ 9:49 AM
Study NCT ID:
NCT00681642
Status:
COMPLETED
Last Update Posted:
2011-01-10
First Post:
2008-05-19
Brief Title:
Corneal Epithelial Wound Healing Difference Between Human Autoserum and Cord Blood Serum
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Phase 1 Study of Comparison of the Effects on Promoting Corneal Epithelial Wound Healing Between Human Autoserum and Cord Blood Serum-in Vitro Cell Culture Experiment
Status:
COMPLETED
Status Verified Date:
2010-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing Umbilical cord serum is also proven to be effective in treatment of dry eye and persistent corneal epithelial defects However there are limited studies comparing the corneal epithelial wound healing promoting effects between these two blood derived products The purpose of this study is to test the corneal epithelial wound healing promoting effects between auto serum and human cord blood serum Primary cultured bovine corneal epithelial cells were used as the model to investigate wound healing cell proliferation and migration by means of scratch corneal wound healing assay evaluation MTS assay and Boyden chamber migration assay in response to human serum and umbilical cord serum The concentrations of EGF TGF-β1 and fibronectin were also compared between human serum and umbilical cord serum with ELISA kits
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None