Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001701
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
1999-11-03
Brief Title:
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Cryptococcus Neoformans Infection in Patients Not Infected With HIV and Complications Associated With Cryptococcus Neoformans Infection
Status:
COMPLETED
Status Verified Date:
2009-10-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans To test this hypothesis we propose to analyze the allelic frequencies of 15 different genes mannose binding lectin Fc-gamma receptor IIa and IIb Fc-gamma receptors IIIa and IIIb myeloperoxidase tumor necrosis factor-alpha and -beta interleukin 1A and 1B interleukin-1 receptor antagonist interleukin-10 NRAMP-1 chitotriosidase and chemokine receptor 5 and their intragenic polymorphic forms and to compare this data to the incidence and severity of C neoformans infection With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive C neoformans infection
Detailed Description:
Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Cryptococcus neoformans To test this hypothesis we propose to analyze the allelic frequencies of 15 different genes mannose binding lectin Fc-gamma receptor IIa and IIb Fc-gamma receptors IIIa and IIIb myeloperoxidase tumor necrosis factor-alpha and -beta interleukin 1A and 1B interleukin-1 receptor antagonist interleukin-10 NRAMP-1 chitotriosidase and chemokine receptor 5 and their intragenic polymorphic forms and to compare this data to the incidence and severity of C neoformans infection With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive C neoformans infection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-C-0137 | None | None | None |