Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004577
Status:
RECRUITING
Last Update Posted:
2024-07-03
First Post:
2000-02-18
Brief Title:
Study of New Magnetic Resonance Imaging Methods of the Brain
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast
Status:
RECRUITING
Status Verified Date:
2024-05-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this investigation is to develop improved magnetic resonance imaging MRI techniques and hardware for studying brain function MRI is a diagnostic tool that provides information about brain chemistry and physiology This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks The MRI machine used in this study is more powerful than those in most hospitals permitting a higher visual resolution
Normal healthy volunteers over 18 years old may be eligible for this study Candidates will be screened with a medical history and questionnaire and a neurological examination Study participants will have a yearly MRI scan For this procedure the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head The scan time varies from 20 minutes to 3 hours most scans last between 45 and 90 minutes During the scan the subject may perform simple tasks such as listening to tapes tapping a finger moving a hand watching a screen or smelling a fragrance More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons
Information from this study will be used to develop better imaging methods that will in turn permit a greater understanding of normal and abnormal brain behaviors
Normal healthy volunteers over 18 years old may be eligible for this study Candidates will be screened with a medical history and questionnaire and a neurological examination Study participants will have a yearly MRI scan For this procedure the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head The scan time varies from 20 minutes to 3 hours most scans last between 45 and 90 minutes During the scan the subject may perform simple tasks such as listening to tapes tapping a finger moving a hand watching a screen or smelling a fragrance More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons
Information from this study will be used to develop better imaging methods that will in turn permit a greater understanding of normal and abnormal brain behaviors
Detailed Description:
Objective
The goal of this protocol is to improve spatial resolution and contrast in MRI studies of brain anatomy and function by developing novel hardware and image acquisition and reconstruction techniques Specifically by improving MRI image quality and manipulating MRI contrast we aim to better characterize and quantify structural chemical and blood flow variations across the brain and study their relationship with neuronal activity For this purpose we will develop and optimize novel MRI techniques on normal healthy volunteers and combine these with EEG and recording of other physiological signals
Study Population
Any healthy male or female volunteer 18 years of age and older the subjects must be capable of understanding the procedures and requirements of this study and be willing to sign an informed consent document
Design
This is a technical development study design to develop and evaluate new MR technology for performing MRI and functional MRI in the CNS with novel contrasts and with a high spatial resolution
Outcome Measures
The primary outcome of this study will be the ability to acquire anatomical and functional images of the human brain with high spatial resolution ie 200-500 micron and 750-1000 micron respectively In addition developed techniques will allow the robust measurement of specific tissue properties including diffusion structural anisotropy iron and myelin content perfusion and metabolite concentrations The relative merits of blood flow and blood oxygenation level dependent BOLD functional MRI fMRI techniques and their particular spatial and temporal signal characteristics will be established It will be determined whether information valuable to interpret BOLD fMRI can be derived from EEG and other physiological signals
The goal of this protocol is to improve spatial resolution and contrast in MRI studies of brain anatomy and function by developing novel hardware and image acquisition and reconstruction techniques Specifically by improving MRI image quality and manipulating MRI contrast we aim to better characterize and quantify structural chemical and blood flow variations across the brain and study their relationship with neuronal activity For this purpose we will develop and optimize novel MRI techniques on normal healthy volunteers and combine these with EEG and recording of other physiological signals
Study Population
Any healthy male or female volunteer 18 years of age and older the subjects must be capable of understanding the procedures and requirements of this study and be willing to sign an informed consent document
Design
This is a technical development study design to develop and evaluate new MR technology for performing MRI and functional MRI in the CNS with novel contrasts and with a high spatial resolution
Outcome Measures
The primary outcome of this study will be the ability to acquire anatomical and functional images of the human brain with high spatial resolution ie 200-500 micron and 750-1000 micron respectively In addition developed techniques will allow the robust measurement of specific tissue properties including diffusion structural anisotropy iron and myelin content perfusion and metabolite concentrations The relative merits of blood flow and blood oxygenation level dependent BOLD functional MRI fMRI techniques and their particular spatial and temporal signal characteristics will be established It will be determined whether information valuable to interpret BOLD fMRI can be derived from EEG and other physiological signals
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-N-0082 | None | None | None |