Ignite Creation Date:
2025-12-24 @ 9:14 PM
Ignite Modification Date:
2025-12-31 @ 1:36 AM
Study NCT ID:
NCT03937804
Status:
COMPLETED
Last Update Posted:
2025-12-24
First Post:
2019-05-03
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
New Approaches for Empowering Studies of Asthma in Populations of African Descent
Sponsor:
National Human Genome Research Institute (NHGRI)
Organization:
Study Overview
Official Title:
New Approaches for Empowering Studies of Asthma in Populations of African Descent
Status:
COMPLETED
Status Verified Date:
2025-08-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background:
Some groups of people have a high prevalence of asthma and allergic disease. Also, asthma and allergic disease are often found in several members of the same family. Researchers want to learn more about what factors might cause asthma, both genetic and environmental.
Objective:
To build a collection of information to try to find genes that cause conditions and disorders such as asthma and allergic disease.
Eligibility:
People ages 18 99 of self-identified African, African American, or African Caribbean descent who either have no history of asthma or wheeze or have a physician s diagnosis of asthma
Design:
Participants will be screened with an interview by phone or in person.
Participants will fill out a questionnaire about their general health and exposure to allergens and smoke.
Participants will have a physical exam.
Participants will have blood tests.
Participants will provide a skin cell sample. Up to two samples will be taken from the inside of the nose. A brush will be used to take the samples.
Participants will have a breathing test. They will be asked to blow forcefully 3 or more times into a lung function machine.
Participants may have their blood and skin samples sent to a lab. DNA will be extracted from the samples and tested.
Participants blood and skin samples will be stored. Samples may be used in future research studies.
...
Some groups of people have a high prevalence of asthma and allergic disease. Also, asthma and allergic disease are often found in several members of the same family. Researchers want to learn more about what factors might cause asthma, both genetic and environmental.
Objective:
To build a collection of information to try to find genes that cause conditions and disorders such as asthma and allergic disease.
Eligibility:
People ages 18 99 of self-identified African, African American, or African Caribbean descent who either have no history of asthma or wheeze or have a physician s diagnosis of asthma
Design:
Participants will be screened with an interview by phone or in person.
Participants will fill out a questionnaire about their general health and exposure to allergens and smoke.
Participants will have a physical exam.
Participants will have blood tests.
Participants will provide a skin cell sample. Up to two samples will be taken from the inside of the nose. A brush will be used to take the samples.
Participants will have a breathing test. They will be asked to blow forcefully 3 or more times into a lung function machine.
Participants may have their blood and skin samples sent to a lab. DNA will be extracted from the samples and tested.
Participants blood and skin samples will be stored. Samples may be used in future research studies.
...
Detailed Description:
Asthma is a complex disease where the interplay between genetic factors and environmental exposures controls susceptibility and disease progression. In the U.S., there remains an epidemic of asthma that disproportionately affects underrepresented minorities and creates a major public health burden, especially among children. Asthmatics of African ancestry continue to have more severe asthma and more severe clinical symptoms than their non-African counterparts, but few studies have focused on this vulnerable group. The purpose of this study is to expand our previous study, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) to integrate multi-omic resources for asthma research in African Diaspora populations and by recruiting new participants. The protocol described herein refers to the recruitment that will take place at the NIH Clinical Center as part of the expansion of CAAPA (CAAPA2).
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| 19-HG-0092 | None | None | View |