Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005345
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Genetic Epidemiology of Blood Lipids and Obesity - Ancillary to NGHS
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct a genetic epidemiologic study of the coronary heart disease CHD risk factors of blood lipids and obesity in Black and white girls who participated in the NHLBI-supported National Growth and Health Study NGHS The study was ancillary to NGHS
Detailed Description:
BACKGROUND
The National Growth and Health Study NGHS was an epidemiologic study of 2379 black and white girls ages 9-10 years at entry who were followed annually The ancillary study had the potential for identifying those genes involved in determining Blackwhite differences in lipid metabolism and obesity This was an exciting area in which there was virtually no available information Finally the study permitted an examination of the effects of gene variation on changes in quantitative levels of blood lipids as well as in body fat during different stages of pubescence since the NGHS protocol included annual anthropometric and maturation assessments and biannual blood lipid determinations along with extensive environmental measures which included dietary household and psychosocial information The study was unique because of the rare opportunity to do genetic analyses in a large cohort of two ethnic groups of children on whom a very rich data base was available
DESIGN NARRATIVE
The study was an independent research project ancillary to the NGHS and utilized the extensive biological and environmental information available from the NGHS core data base Blood samples were obtained from 1133 girls seen at their followup examinations in Year 7 in order to determine genotypes at those loci known to be implicated in lipid metabolism and obesity Both protein apolipoproteins C-II D and E and LPa and DNA apolipoprotein B lipoprotein lipase LPL and LDL receptor were analyzed The distribution of genetic variation within each ethnic group was determined At each candidate gene locus the genotype effects were estimated on quantitative level of apolipoproteins and lipoproteins and also on the degree and distribution of body fat after adjusting for concomitant variables such as age biologic maturation stage adiposity within each ethnic group By comparing the frequencies of genotypes at candidate loci their allelic effects were assessed as well as their impact on blood lipids and obesity development in Black and white females
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The National Growth and Health Study NGHS was an epidemiologic study of 2379 black and white girls ages 9-10 years at entry who were followed annually The ancillary study had the potential for identifying those genes involved in determining Blackwhite differences in lipid metabolism and obesity This was an exciting area in which there was virtually no available information Finally the study permitted an examination of the effects of gene variation on changes in quantitative levels of blood lipids as well as in body fat during different stages of pubescence since the NGHS protocol included annual anthropometric and maturation assessments and biannual blood lipid determinations along with extensive environmental measures which included dietary household and psychosocial information The study was unique because of the rare opportunity to do genetic analyses in a large cohort of two ethnic groups of children on whom a very rich data base was available
DESIGN NARRATIVE
The study was an independent research project ancillary to the NGHS and utilized the extensive biological and environmental information available from the NGHS core data base Blood samples were obtained from 1133 girls seen at their followup examinations in Year 7 in order to determine genotypes at those loci known to be implicated in lipid metabolism and obesity Both protein apolipoproteins C-II D and E and LPa and DNA apolipoprotein B lipoprotein lipase LPL and LDL receptor were analyzed The distribution of genetic variation within each ethnic group was determined At each candidate gene locus the genotype effects were estimated on quantitative level of apolipoproteins and lipoproteins and also on the degree and distribution of body fat after adjusting for concomitant variables such as age biologic maturation stage adiposity within each ethnic group By comparing the frequencies of genotypes at candidate loci their allelic effects were assessed as well as their impact on blood lipids and obesity development in Black and white females
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL045778 | NIH | None | httpsreporternihgovquickSearchR01HL045778 |