Ignite Creation Date:
2024-05-05 @ 7:25 PM
Last Modification Date:
2024-10-26 @ 9:48 AM
Study NCT ID:
NCT00667030
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-11-13
First Post:
2008-04-23
Brief Title:
Aging Lifestyle and Inflammation in Veterans Exercising
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Aging Lifestyle and Inflammation in Veterans Exercising
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ALIVE
Brief Summary:
Over half of adults in this country are overweight This increases risk for heart and blood pressure problems cancer stroke and arthritis While it is difficult to lose large amounts of weight and keep it off even small amounts of weight loss can improve health Furthermore fat is increasingly recognized as a source of substances that increase inflammation It may be that some of the adverse consequences of being overweight are due to increased inflammation We are asking you to volunteer for a research study in which you may lose a moderate amount of weight and increase your activity It is important that you read and understand the information on this form
The purposes of these studies are to determine the influences of age and body composition on the production of inflammatory chemicals by fat adipose tissue the mechanisms controlling this and if a weight loss and aerobic exercise intervention results in a decrease in inflammation
The purposes of these studies are to determine the influences of age and body composition on the production of inflammatory chemicals by fat adipose tissue the mechanisms controlling this and if a weight loss and aerobic exercise intervention results in a decrease in inflammation
Detailed Description:
Adipose tissue is increasingly recognized as more than an inert depot serving not only to accept and store excess energy in the form of triglycerides but also to secrete hormones and adipokines that have substantial effects on lipid and glucose metabolism Furthermore there are depot differences in metabolic function as well as adipokine content However the physiology both underlying and consequential to these observations remains unknown This research is therefore designed to examine
1 the effects of aging and obesity on regional adipokine secretion and expression 2 whether elevated adipokine levels in older obese people are due to increased macrophage infiltration into subcutaneous adipose tissue andor related to total subcutaneous or visceral abdominal fat SAT or VAT distribution and 3 the relationship of adipokines to insulin resistance and the constituents of the metabolic syndrome
Specifically we aim to determine
1 if the expression and secretion of a the inflammatory markers SAA IL-6 TNF-a MCP-1 is greater and b the anti-inflammatory hormone adiponectin is lower in SC abdominal and gluteal adipose tissue from older compared to middle-aged and younger obese subjects across a narrow range of obesity and waist circumference
2 if these age-associated changes in adipokine production are adue to the degree of macrophage infiltration of regional adipose tissue andor differences in a greater degree of visceral andor differences in ABD fat distribution SAT VAT and b related to glucose and lipid metabolic profiles of the subjects and
3 the effects of a WLAEX intervention on regional adipokine expression and secretion circulating levels of CRP and the above adipokines and glucose and lipid metabolism in a subset of obese sedentary individuals with greater than two components of the metabolic syndrome
1 the effects of aging and obesity on regional adipokine secretion and expression 2 whether elevated adipokine levels in older obese people are due to increased macrophage infiltration into subcutaneous adipose tissue andor related to total subcutaneous or visceral abdominal fat SAT or VAT distribution and 3 the relationship of adipokines to insulin resistance and the constituents of the metabolic syndrome
Specifically we aim to determine
1 if the expression and secretion of a the inflammatory markers SAA IL-6 TNF-a MCP-1 is greater and b the anti-inflammatory hormone adiponectin is lower in SC abdominal and gluteal adipose tissue from older compared to middle-aged and younger obese subjects across a narrow range of obesity and waist circumference
2 if these age-associated changes in adipokine production are adue to the degree of macrophage infiltration of regional adipose tissue andor differences in a greater degree of visceral andor differences in ABD fat distribution SAT VAT and b related to glucose and lipid metabolic profiles of the subjects and
3 the effects of a WLAEX intervention on regional adipokine expression and secretion circulating levels of CRP and the above adipokines and glucose and lipid metabolism in a subset of obese sedentary individuals with greater than two components of the metabolic syndrome
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None