Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001310
Status:
TERMINATED
Last Update Posted:
2019-12-09
First Post:
1999-11-03
Brief Title:
Tissue Studies of Human Eye Diseases
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Immunopathology and Molecular Pathology of Ocular Diseases in Humans
Status:
TERMINATED
Status Verified Date:
2015-09-16
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival corneal uveal vitreoretinal and optic nerve disorders ocular degenerative metabolic or genetic diseases and tumors These will be studied using light microscopy electron microscopy confocal microscopy immunohistochemistry molecular pathological including polymerase chain reaction and in situ hybridization as well as measuring the functions of cellular organelles eg mitochondrial function Lymphocytes in the peripheral blood as well as other involved biopsied tissues and ocular tissue will be compared and categorized by disease Cytokines chemokines or growth factors andor other released molecules in the blood and ocular fluids will be also analyzed Elucidating the relationship between the infiltrating cells ocular resident cells and their products in various diseases will help us to make diagnoses and increase our understanding of human ocular disorders
Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study The tissues will be examined under microscope and studied using sophisticated chemical and biological tests Immune cells from blood samples may also be examined These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies
Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study The tissues will be examined under microscope and studied using sophisticated chemical and biological tests Immune cells from blood samples may also be examined These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies
Detailed Description:
The purpose of this project is to diagnose and evaluate ocular and related tissues with various diseases such as conjunctival corneal uveal vitreoretinal scleral optic nerve and orbital disorders ocular degenerative inflammatory metabolic or genetic diseases and tumors These will be studied using light microscopy electron microscopy confocal microscopy immunohistochemistry molecular pathology including microdissection and polymerase chain reaction and in situ hybridization ELISA as well as measuring the functions of cellular organelles eg mitochondrial function Lymphocytes in the peripheral blood serum as well as other involved biopsied tissues and ocular tissue will be compared and categorized by disease and normal Cytokines chemokines growth factors antibodies andor other released molecules in the blood CSF and ocular fluids will be also analyzed We will compare the tissue morphology as well as immunological and biochemical indexes eg cytokinechemokine levels growth factors and antibodies between the diseases and normals Elucidating the relationship between the infiltrating cells ocular resident cells and their products in various diseases will help us to make diagnoses increase our understanding of human ocular disorders and assist therapy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 92-EI-0113 | None | None | None |