Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001469
Status:
COMPLETED
Last Update Posted:
2020-03-16
First Post:
1999-11-03
Brief Title:
Genetic Analysis of Hereditary Prostate Cancer
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetic Analysis of Hereditary Prostate Cancer
Status:
COMPLETED
Status Verified Date:
2020-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Molecular approaches to the understanding of human neoplastic disease have revealed that multiple genetic alterations are an essential component of tumorigenesis Both germline and somatic genetic alterations can be involved in the malignant transformation of normal cells Identification of the genes involved in neoplastic transformation has been approached through the molecular analysis of sporadic cancers and the genetic study of families with an inherited predisposition for cancer The interplay of these two approaches has led to the characterization of genes such as the retinoblastoma Rb gene the p53 gene and the adenomatous polyposis coli APC gene that are all involved in the development of both hereditary and non-hereditary forms of cancer Inherited mutations in such genes predispose affected families to hereditary cancer syndromes affording an opportunity to identify genetic lesions that also cause the more common sporadic cancers
Prostate cancer PRCA is the most common cancer diagnosed 1999 estimate 179300 cases and the second leading cause of cancer mortality 1999 estimate 37000 deaths in men in the United States Family history is the single strongest risk factor currently known for prostate cancer This raises the possibility that heritable genetic factors may be involved in the development of this disease in a subset of men The genetic contribution to diseases of complex origin such as cancer is often most salient in families of early onset cases Therefore prostate cancer inheritance following a simple Mendelian pattern may be identified in the families of probands with early-onset cases Common susceptibility alleles of small effect may be detectable in families with later-onsent andor less strong family history of PRCA or in case-control data
Prostate cancer PRCA is the most common cancer diagnosed 1999 estimate 179300 cases and the second leading cause of cancer mortality 1999 estimate 37000 deaths in men in the United States Family history is the single strongest risk factor currently known for prostate cancer This raises the possibility that heritable genetic factors may be involved in the development of this disease in a subset of men The genetic contribution to diseases of complex origin such as cancer is often most salient in families of early onset cases Therefore prostate cancer inheritance following a simple Mendelian pattern may be identified in the families of probands with early-onset cases Common susceptibility alleles of small effect may be detectable in families with later-onsent andor less strong family history of PRCA or in case-control data
Detailed Description:
Molecular approaches to the understanding of human neoplastic disease have revealed that multiple genetic alterations are an essential component of tumorigenesis Both germline and somatic genetic alterations can be involved in the malignant transformation of normal cells Identification of the genes involved in neoplastic transformation has been approached through the molecular analysis of sporadic cancers and the genetic study of families with an inherited predisposition for cancer The interplay of these two approaches has led to the characterization of genes such as the retinoblastoma Rb gene the p53 gene and the adenomatous polyposis coli APC gene that are all involved in the development of both hereditary and non-hereditary forms of cancer Inherited mutations in such genes predispose affected families to hereditary cancer syndromes affording an opportunity to identify genetic lesions that also cause the more common sporadic cancers
Prostate cancer PRCA is the most common cancer diagnosed 1999 estimate 179300 cases and the second leading cause of cancer mortality 1999 estimate 37000 deaths in men in the United States Family history is the single strongest risk factor currently known for prostate cancer This raises the possibility that heritable genetic factors may be involved in the development of this disease in a subset of men The genetic contribution to diseases of complex origin such as cancer is often most salient in families of early onset cases Therefore prostate cancer inheritance following a simple Mendelian pattern may be identified in the families of probands with early-onset cases Common susceptibility alleles of small effect may be detectable in families with later-onset andor less strong family history of PRCA or in case-control data
Prostate cancer PRCA is the most common cancer diagnosed 1999 estimate 179300 cases and the second leading cause of cancer mortality 1999 estimate 37000 deaths in men in the United States Family history is the single strongest risk factor currently known for prostate cancer This raises the possibility that heritable genetic factors may be involved in the development of this disease in a subset of men The genetic contribution to diseases of complex origin such as cancer is often most salient in families of early onset cases Therefore prostate cancer inheritance following a simple Mendelian pattern may be identified in the families of probands with early-onset cases Common susceptibility alleles of small effect may be detectable in families with later-onset andor less strong family history of PRCA or in case-control data
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 95-HG-0158 | None | None | None |