Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001486
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
1999-11-03
Brief Title:
Genetic Study of Schizophrenia
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Neurobiological Investigation of Patients With Schizophrenia Spectrum Disorders and Their Siblings
Status:
RECRUITING
Status Verified Date:
2024-09-18
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This large ongoing study at NIMH investigates the neurobiology of schizophrenia by identifying susceptibility genes evaluating their impact on brain function to better understand how to treat and prevent this illness
Detailed Description:
Objective Schizophrenia is a complex genetic disorder which likely involves many genes each producing a slight increase in risk Finding weak-acting genes in complex genetic disorders has been challenging and will likely require a number of approaches and large clinical samples Several strategies have emerged recently that appear to markedly improve the power of genetic studies for detecting such genes These include using association rather than linkage and using intermediate phenotypes in addition to DMS-IV diagnosis
Study Population We propose to take advantage of these techniques by studying quantitative traits related to schizophrenia in patients siblings and controls
Design We will employ an association design rather than linkage Traits will include quantifiable neurobiological variables that have been implicated previously as possible phenotypes related to schizophrenia These include tests of attention and cognition
Outcome Measure We will use several statistical methods to show that specific genetic polymorphisms affect these phenotypes including case control and family based association studies
Study Population We propose to take advantage of these techniques by studying quantitative traits related to schizophrenia in patients siblings and controls
Design We will employ an association design rather than linkage Traits will include quantifiable neurobiological variables that have been implicated previously as possible phenotypes related to schizophrenia These include tests of attention and cognition
Outcome Measure We will use several statistical methods to show that specific genetic polymorphisms affect these phenotypes including case control and family based association studies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 95-M-0150 | None | None | None |