Ignite Creation Date:
2024-05-05 @ 7:22 PM
Last Modification Date:
2024-10-26 @ 9:47 AM
Study NCT ID:
NCT00650780
Status:
COMPLETED
Last Update Posted:
2008-04-02
First Post:
2008-03-30
Brief Title:
Vitamin D Binding Protein Gc Allele Variation Effects Response to Vitamin D Treatment
Sponsor:
Creighton University
Organization:
Creighton University
Study Overview
Official Title:
Vitamin D Binding Protein Gc Allele Variation Effects Response to Vitamin D Treatment
Status:
COMPLETED
Status Verified Date:
2008-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Gc
Brief Summary:
We have just completed a randomized clinical trial of 100000 IU Vitamin D3 given as a single dose at the beginning of winter We found a wide range of responses to the dose This study proposes that genetic differences account for some of the variation in response of 25OHD levels after treatment with oral Vitamin D
Detailed Description:
We suspect that the wide range of response is effected by other factors such as variation in Vitamin D binding protein the major transporter of Vitamin D metabolites
Gc also known as Vitamin D binding protein DBP group specific component or Gc globulin is a 52-58 kDa multifunctional plasma protein synthesized in the liver The gene encoding for Gc is located on chromosome 4 and three common co-dominant alleles give rise to three phenotypes Gc1s Gc1f and Gc2 Gc binds actin recruits neutrophil leukocytes and converts into a macrophage- and osteoclast- activating factor It also is the major transporter of Vitamin D and its metabolites Lauridsen et al showed that Gc phenotype correlates with 25OHD levels in a group of postmenopausal women
This study proposes that Gc phenotype accounts for some of the variation in response of 25OHD levels after treatment with oral Vitamin D
Gc also known as Vitamin D binding protein DBP group specific component or Gc globulin is a 52-58 kDa multifunctional plasma protein synthesized in the liver The gene encoding for Gc is located on chromosome 4 and three common co-dominant alleles give rise to three phenotypes Gc1s Gc1f and Gc2 Gc binds actin recruits neutrophil leukocytes and converts into a macrophage- and osteoclast- activating factor It also is the major transporter of Vitamin D and its metabolites Lauridsen et al showed that Gc phenotype correlates with 25OHD levels in a group of postmenopausal women
This study proposes that Gc phenotype accounts for some of the variation in response of 25OHD levels after treatment with oral Vitamin D
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None