Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005168
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Hyperapo B and Coronary Heart Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the role of apolipoprotein B and apolipoprotein A1 in the etiology of coronary artery disease
Detailed Description:
BACKGROUND
Hyperapo B is a phenotype defined as elevated plasma level of the major apoprotein B of low density lipoproteins in the presence of a normal plasma level of low density lipoprotein cholesterol It has been demonstrated that hyperapo B is strongly associated with coronary artery disease In 1984 when the study began the independence of this association with other risk factors for coronary artery disease such as cigarette smoking hypertension and low plasma levels of high density lipoproteins was not known The study improved knowledge of the pathophysiology of coronary artery disease and of the genetic and biochemical defects of hyperapo B and hypoalphalipoproteinemia
DESIGN NARRATIVE
Interviews were conducted and clinical data collected on each index case and spouse as well as on first degree relatives Risk factor data included blood pressure blood lipid levels obesity cigarette smoking fasting blood sugar and diabetes hormone use and menopause for women physical activity personality scores and family history Clinical data included the indications for coronary arteriography history of use of lipid-lowering agents and insulin presence of corneal arcus xanthomata and xanthelasma and the electrocardiogram
To determine if the apolipoprotein B gene and the apolipoprotein A1-C3-A4 gene cluster were independent predictors of premature coronary disease the relation between DNA polymeric sites within the two genes and coronary disease were investigated using cloned DNA fragments as molecular probes To determine if apolipoprotein B and apolipoprotein A levels aggregated in families and to determine if hyperapo B and hypoalphalipoproteinemia segregated as Mendelian traits genetic analysis was conducted in the 200 index cases and the 900 first degree relatives Studies were also conducted on the linkages between hyperapo B and haplotypes of the apolipoprotein B gene on hyperapo B and the Ag polymorphisms and on hyperalphalipoproteinemia and haplotypes of the apolipoprotein A1-C3-A4 gene cluster
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Hyperapo B is a phenotype defined as elevated plasma level of the major apoprotein B of low density lipoproteins in the presence of a normal plasma level of low density lipoprotein cholesterol It has been demonstrated that hyperapo B is strongly associated with coronary artery disease In 1984 when the study began the independence of this association with other risk factors for coronary artery disease such as cigarette smoking hypertension and low plasma levels of high density lipoproteins was not known The study improved knowledge of the pathophysiology of coronary artery disease and of the genetic and biochemical defects of hyperapo B and hypoalphalipoproteinemia
DESIGN NARRATIVE
Interviews were conducted and clinical data collected on each index case and spouse as well as on first degree relatives Risk factor data included blood pressure blood lipid levels obesity cigarette smoking fasting blood sugar and diabetes hormone use and menopause for women physical activity personality scores and family history Clinical data included the indications for coronary arteriography history of use of lipid-lowering agents and insulin presence of corneal arcus xanthomata and xanthelasma and the electrocardiogram
To determine if the apolipoprotein B gene and the apolipoprotein A1-C3-A4 gene cluster were independent predictors of premature coronary disease the relation between DNA polymeric sites within the two genes and coronary disease were investigated using cloned DNA fragments as molecular probes To determine if apolipoprotein B and apolipoprotein A levels aggregated in families and to determine if hyperapo B and hypoalphalipoproteinemia segregated as Mendelian traits genetic analysis was conducted in the 200 index cases and the 900 first degree relatives Studies were also conducted on the linkages between hyperapo B and haplotypes of the apolipoprotein B gene on hyperapo B and the Ag polymorphisms and on hyperalphalipoproteinemia and haplotypes of the apolipoprotein A1-C3-A4 gene cluster
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL031497 | NIH | None | httpsreporternihgovquickSearchR01HL031497 |