Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00004329
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
1999-10-18
Brief Title:
Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2003-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES I Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist clonidine and the antagonist yohimbine of the alpha-2 adrenergic receptor in 6 patients with regional lipoatrophy and in 6 controls
II Determine the full sequence of the alpha-2 adrenergic receptor structural gene in genomic DNA from peripheral blood leukocytes
II Determine the full sequence of the alpha-2 adrenergic receptor structural gene in genomic DNA from peripheral blood leukocytes
Detailed Description:
PROTOCOL OUTLINE Antihypertensives are held beginning 3 days before the first study day
An oral challenge is administered as follows clonidine on day 1 yohimbine on day 2 The order of administration is reversed in alternate subjects
Timed measurements of norepinephrine glycerol and free fatty acids follow each challenge Structural gene sequencing is evaluated for each participant
An oral challenge is administered as follows clonidine on day 1 yohimbine on day 2 The order of administration is reversed in alternate subjects
Timed measurements of norepinephrine glycerol and free fatty acids follow each challenge Structural gene sequencing is evaluated for each participant
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UTMB-437 | None | None | None |