Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006322
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-10-02
Brief Title:
Birth Weight Effect on Blood Pressure in Late Childhood
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the relationship of birth weight and childhood blood pressure
Detailed Description:
BACKGROUND
Cardiovascular diseases are the leading causes of morbidity and mortality in the United States On the basis of an interplay of genetic and environmental factors these diseases appear to be rooted in childhood Recent reports implicate the intrauterine nutritional environment regulating fetal growth as a determinant of adult cardiovascular disease According to this concept impaired fetal growth with consequent lower birth weight results in alteration in organ structure and subsequent functional impairment in later life Higher blood pressure BP has been suggested as the possible link between compromised intrauterine growth and the long-term risk for cardiovascular disease Despite the many reports which appear to support the low birth weight - high BP hypothesis this concept is in conflict with the body of data on the association of BP with body size in childhood adolescence and adulthood which consistently demonstrates a direct relationship between body weight and BP
The results of this prospective study contributed an objective body of data to this important issue If birth measures reflecting intrauterine exposure do contribute significantly to BP in later childhood then studies focused on the mechanisms regulating this risk are justified Alternatively if post-natalchildhood parameters are the major determinants of later BP then efforts should focus on effective preventive strategies in childhood such as obesity
DESIGN NARRATIVE
To examine the low birth weight - high blood pressure concept the investigators conducted a prospective study on a cohort of children who were well characterized at birth In 1988 data on weight length BP gestation and maternal health were obtained on 1160 newborn cases representing a range of birth weight and gestational age They re-examined these children at age 11-13 years to test the overall hypothesis that birth weight as well as other newborn measures of intrauterine growth did not correlate with BP at age 11-13 years The aims of the project were to 1 determine if birth weight contributed to BP andor body size in childhood 2 determine if the duration of intrauterine growth in terms of gestational age contributed to BP and body size 3 determine if newborn ponderal index a measure of relative fetal growth contributed to BP and body size and 4 determine the relative contribution of newborn measures of birth weight gestational age BP ponderal index and maternal health to BP and body size in late childhood
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Cardiovascular diseases are the leading causes of morbidity and mortality in the United States On the basis of an interplay of genetic and environmental factors these diseases appear to be rooted in childhood Recent reports implicate the intrauterine nutritional environment regulating fetal growth as a determinant of adult cardiovascular disease According to this concept impaired fetal growth with consequent lower birth weight results in alteration in organ structure and subsequent functional impairment in later life Higher blood pressure BP has been suggested as the possible link between compromised intrauterine growth and the long-term risk for cardiovascular disease Despite the many reports which appear to support the low birth weight - high BP hypothesis this concept is in conflict with the body of data on the association of BP with body size in childhood adolescence and adulthood which consistently demonstrates a direct relationship between body weight and BP
The results of this prospective study contributed an objective body of data to this important issue If birth measures reflecting intrauterine exposure do contribute significantly to BP in later childhood then studies focused on the mechanisms regulating this risk are justified Alternatively if post-natalchildhood parameters are the major determinants of later BP then efforts should focus on effective preventive strategies in childhood such as obesity
DESIGN NARRATIVE
To examine the low birth weight - high blood pressure concept the investigators conducted a prospective study on a cohort of children who were well characterized at birth In 1988 data on weight length BP gestation and maternal health were obtained on 1160 newborn cases representing a range of birth weight and gestational age They re-examined these children at age 11-13 years to test the overall hypothesis that birth weight as well as other newborn measures of intrauterine growth did not correlate with BP at age 11-13 years The aims of the project were to 1 determine if birth weight contributed to BP andor body size in childhood 2 determine if the duration of intrauterine growth in terms of gestational age contributed to BP and body size 3 determine if newborn ponderal index a measure of relative fetal growth contributed to BP and body size and 4 determine the relative contribution of newborn measures of birth weight gestational age BP ponderal index and maternal health to BP and body size in late childhood
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL060858 | NIH | None | httpsreporternihgovquickSearchR01HL060858 |