Ignite Creation Date:
2025-12-24 @ 7:58 PM
Ignite Modification Date:
2025-12-28 @ 7:40 PM
Study NCT ID:
NCT05427604
Status:
COMPLETED
Last Update Posted:
2022-06-22
First Post:
2022-05-30
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
To Evaluate the Effects of Omega 3 Fatty Acids in the Context of Cancer Prevention
Sponsor:
Université Catholique de Louvain
Organization:
Study Overview
Official Title:
To Evaluate the Effects of Omega 3 Fatty Acids in the Context of Cancer Prevention
Status:
COMPLETED
Status Verified Date:
2022-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Previous studies have demonstrated, in an in vitro micro-tumour model (the spheroid) and in a mouse model, that long-chain omega-3 fatty acids, in particular docosahexaenoic acid (DHA), can inhibit tumour development.
Therefore, the aim of this study was to collect DHA-enriched human serum, following ingestion of a DHA-enriched oil, in order to assess its effect on tumour development in vitro. Blood enriched in fatty acids not containing DHA will be used as a control condition, obtained after ingestion of olive oil.
This study is an important step to determine the interest of DHA supplementation as a new approach to prevent tumour development, and/or as an adjuvant to cancer treatments.
Therefore, the aim of this study was to collect DHA-enriched human serum, following ingestion of a DHA-enriched oil, in order to assess its effect on tumour development in vitro. Blood enriched in fatty acids not containing DHA will be used as a control condition, obtained after ingestion of olive oil.
This study is an important step to determine the interest of DHA supplementation as a new approach to prevent tumour development, and/or as an adjuvant to cancer treatments.
Detailed Description:
The objective of this study is to collect DHA-enriched human serum in order to test it on the in vitro tumour model, spheroids. The results will be compared with human serum enriched in fatty acids (saturated, monounsaturated and polyunsaturated) but not in DHA.
To do this, the study will be divided into 4 steps
1. determination of the time when a maximum concentration of fatty acids is observed in the serum after ingestion of olive oil (the control condition)
2. blood sampling at baseline (fasting) and at Tmax after olive oil ingestion
3. determination of the time when a maximum concentration of fatty acids is observed in the serum after ingestion of DHA-enriched oil (the test condition)
4. blood sampling at baseline (fasting) and at Tmax after ingestion of DHA-enriched oil.
To do this, the study will be divided into 4 steps
1. determination of the time when a maximum concentration of fatty acids is observed in the serum after ingestion of olive oil (the control condition)
2. blood sampling at baseline (fasting) and at Tmax after olive oil ingestion
3. determination of the time when a maximum concentration of fatty acids is observed in the serum after ingestion of DHA-enriched oil (the test condition)
4. blood sampling at baseline (fasting) and at Tmax after ingestion of DHA-enriched oil.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: