Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005365
Status:
COMPLETED
Last Update Posted:
2016-02-10
First Post:
2000-05-25
Brief Title:
Central Obesity and Disease Risk in Japanese Americans
Sponsor:
University of Washington
Organization:
University of Washington
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease ASCVD in a previously-examined cross-sectional cohort of second-generation Japanese Americans and in a newly-recruited cohort of third generation Japanese Americans
Detailed Description:
BACKGROUND
The study was conducted in response to a program announcment issued in 1991 on obesity and tests the hypothesis that atherosclerotic cardiovascular disease ASCVD hypertension andor non-insulin dependent diabetes mellitus NIDDM develop in Japanese Americans when there is a truncal pattern of weight gain central adiposity which is in turn accompanied by insulin resistance hyperinsulinemia and lipid abnormalities This cluster of abnormalities has been called Syndrome X It is postulated that Syndrome X develops in Japanese Americans in response to environmental behavioral factors many of which reflect westernization in this ethnic group The research plan focuses upon the relationship between central obesity and metabolic changes and disease outcomes associated with Syndrome X along with the behavioral variables that potential risk factors for the development of this cluster of abnormalities
DESIGN NARRATIVE
The cohort was re-examined for diabetes hypertension coronary heart disease peripheral vascular disease and a number of potential coronary heart disease risk factors including medical history health practice social history diet glycosylated hemoglobin insulin proinsulin c-peptide glucose anthrometric measurements lipids and computed tomography on the thorax abdomen and thigh
The study was conducted in response to a program announcment issued in 1991 on obesity and tests the hypothesis that atherosclerotic cardiovascular disease ASCVD hypertension andor non-insulin dependent diabetes mellitus NIDDM develop in Japanese Americans when there is a truncal pattern of weight gain central adiposity which is in turn accompanied by insulin resistance hyperinsulinemia and lipid abnormalities This cluster of abnormalities has been called Syndrome X It is postulated that Syndrome X develops in Japanese Americans in response to environmental behavioral factors many of which reflect westernization in this ethnic group The research plan focuses upon the relationship between central obesity and metabolic changes and disease outcomes associated with Syndrome X along with the behavioral variables that potential risk factors for the development of this cluster of abnormalities
DESIGN NARRATIVE
The cohort was re-examined for diabetes hypertension coronary heart disease peripheral vascular disease and a number of potential coronary heart disease risk factors including medical history health practice social history diet glycosylated hemoglobin insulin proinsulin c-peptide glucose anthrometric measurements lipids and computed tomography on the thorax abdomen and thigh
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL049293 | NIH | None | httpsreporternihgovquickSearchR01HL049293 |