Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001648
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
1999-11-03
Brief Title:
Structure of the Herpes Simplex Virus Receptor
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Polymorphism of the Herpes Simplex Virus Receptor
Status:
COMPLETED
Status Verified Date:
2010-04-13
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the structure of the receptor molecule for the herpes simplex virus HSV and determine if the receptors structure is related to susceptibility to infection with the virus There are two types of herpes virus-HSV-1 and HSV-2 HSV-1 commonly causes cold sores and HSV-2 usually causes genital herpes The herpes virus enters infects cells through protein molecules on the cells surface This study will explore possible differences between the structure of the HSV receptor molecule in different people to understand better how infection occurs The study will also look at proteins on white blood cells Fc receptors cytokines and mannose binding protein that may influence the risk of infection with HSV Information from this study may lead to new treatments to prevent HSV infection
People 18 years of age and older who are infected with HSV and people who are not infected with the virus may be eligible for this study Participants will have blood drawn to confirm whether or not they have been infected with the virus The blood sample will also be used to study the genes for the HSV receptor Fc receptors cytokines mannose binding protein and related proteins on the white blood cells No more than 40 milliliters 8 teaspoons of blood will be drawn
Participants who are found to have antibodies to HSV-2 will be offered counseling and advice on practicing safe sex techniques to help prevent sexually transmitted diseases including HSV-2 infection
People 18 years of age and older who are infected with HSV and people who are not infected with the virus may be eligible for this study Participants will have blood drawn to confirm whether or not they have been infected with the virus The blood sample will also be used to study the genes for the HSV receptor Fc receptors cytokines mannose binding protein and related proteins on the white blood cells No more than 40 milliliters 8 teaspoons of blood will be drawn
Participants who are found to have antibodies to HSV-2 will be offered counseling and advice on practicing safe sex techniques to help prevent sexually transmitted diseases including HSV-2 infection
Detailed Description:
Herpes simplex virus HSV causes genital orolabial or cutaneous lesions keratitis and encephalitis Recently cellular receptors for HSV were isolated The purpose of this study is to identify polymorphisms in the sequence of HSV receptor cytokines or chemokines and to determine whether these polymorphisms correlate with susceptibility to infection by HSV or with symptoms of HSV Blood samples from individuals who are seronegative or seropositive with or without symptoms of infection for HSV-2 will be analyzed to determine the sequences of the HSV receptors cytokines chemokines or related proteins If a new genetic polymorphism is found additional blood samples from individuals who are seropositive for HSV and from random blood donors will be analyzed to determine the frequency of the polymorphisms in seropositives and in the general population Knowledge gained from this study should provide important insights into mechanisms of infection by HSV and may lead to novel therapies to block infection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 97-I-0166 | None | None | None |