Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006498
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-11-16
Brief Title:
Chronic Life Stress and Incident Asthma in Adult Women
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2006-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To prospectively examine the association between a specific chronic life stressor ie intimate violence exposure and adult asthma in women
Detailed Description:
BACKGROUND
Etiologies of the rising prevalence and morbidity of asthma are not well understood Knowledge gaps are particularly significant with respect to adult-onset asthma The role of stress in the expression of asthma is largely unexplored in large-scale prospective epidemiologic studies and such investigation has been identified as a priority by a recent NHLBI expert panel
DESIGN NARRATIVE
The study prospectively examines the association between a specific chronic life stressor ie intimate violence exposure and adult asthma in women participating in the Nurses Health Study II cohort Emerging epidemiologic data suggest that exposure to intimate violence is a pervasive chronic life stressor associated with adverse impact on womens psychological and physical health Traumatic stress such as that related to intimate violence exposure has been associated with neuroendocrine changes known to cause alterations in neuroendocrine and immune functions important to the pathophysiology of inflammatory diseases including asthma The investigators are testing the hypothesis that women exposed to high-level chronic stress violence will be at greater risk for asthma development than women with low-level stress violence exposure The influence of chronic stress on neuroendocrine and immune function as reflected in morning cortisol expression for the former and cytokine profiles and IgE production T-helper cell polarization for the latter will also be examined in a nested case control fashion among these women
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Etiologies of the rising prevalence and morbidity of asthma are not well understood Knowledge gaps are particularly significant with respect to adult-onset asthma The role of stress in the expression of asthma is largely unexplored in large-scale prospective epidemiologic studies and such investigation has been identified as a priority by a recent NHLBI expert panel
DESIGN NARRATIVE
The study prospectively examines the association between a specific chronic life stressor ie intimate violence exposure and adult asthma in women participating in the Nurses Health Study II cohort Emerging epidemiologic data suggest that exposure to intimate violence is a pervasive chronic life stressor associated with adverse impact on womens psychological and physical health Traumatic stress such as that related to intimate violence exposure has been associated with neuroendocrine changes known to cause alterations in neuroendocrine and immune functions important to the pathophysiology of inflammatory diseases including asthma The investigators are testing the hypothesis that women exposed to high-level chronic stress violence will be at greater risk for asthma development than women with low-level stress violence exposure The influence of chronic stress on neuroendocrine and immune function as reflected in morning cortisol expression for the former and cytokine profiles and IgE production T-helper cell polarization for the latter will also be examined in a nested case control fashion among these women
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL064108 | NIH | None | httpsreporternihgovquickSearchR01HL064108 |