Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06657781
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-22
Brief Title:
Study and Role of Inflammasome in Platelet Activation During Bacterial Andor Viral Sepsis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Study and Role of Inflammasome in Platelet Activation During Bacterial Andor Viral Sepsis
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PLAQSEPSIS
Brief Summary:
Sepsis now defined as life-threatening organ dysfunction due to a dysregulated host response to infection is an important global health problem representing about a fifth of all global deaths It can be associated in some cases with multiple organ failure and cytokine storm The main objective of this study is to estimate and to compare the activation rate of the Nucleotide-binding domain Leucine Rich repeat containing Protein 3 NLRP3 inflammasome in platelets between five groups of patients suffering from bacterial andor viral sepsis with different severity levels according to Sequential Organ Failure Assessment SOFA score to precise the platelets implication in this cytokine storm
Detailed Description:
Patients with bacterial or vial sepsis have been shown to exhibit very high levels of pro-inflammatory cytokines IL1 IL6 IFN IP10 and MCP1 that may activate the T-helper-1 lymphocytic response Th1 These cytokines can be produced by several cell types including blood platelets IL1 is an important pro-inflammatory cytokine whose expression is increased in various pro-inflammatory contexts including dengue infection It induces an increase in endothelial permeability and a pro-thrombotic state as described in patients infected with COVID-19 It is synthesized as a protein precursor that is cleaved by the NLRP3 Nucleotide-binding domain Leucine repeat Rich containing Protein 3 Close associations between the deregulation of inflammasome activity and hereditary or acquired diseases suggest an important role of NLRP3 inflammasome in regulating immune responses The activation of the NLRP3 inflammasome increases caspase 1 activity and induces the production of bioactive IL1 as well as other pro-inflammatory cytokines such as IL18 The major role of NLRP3 platelet inflammasome in the cytokine storm has been highlighted in the case of Dengue virus infection We hypothesize that blood platelets may play an important role in the inflammatory response observed during sepsis through the activation of NLRP3 inflammasome particularly during its exacerbation
Five groups of patients will be constituted patients with leptospirosis patients with bacterial infections including in-hospital-acquired-infections patients with viral infection patients non infected control group patients with viral infection SARS-COv2
Only one blood collection will be realized
Five groups of patients will be constituted patients with leptospirosis patients with bacterial infections including in-hospital-acquired-infections patients with viral infection patients non infected control group patients with viral infection SARS-COv2
Only one blood collection will be realized
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None