Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06656572
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-22
Brief Title:
Immunogenomic Analyses of Pediatric Catatonia
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Immunogenomic Analyses of Pediatric Catatonia
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Rady Childrens Institute for Genomic Medicine seeks to understand the genomes and immune systems in 40 children and adolescents who are admitted to Rady Childrens Hospital San Diego with a catatonia diagnosis Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of catatonia and impact care The investigator also hopes to identify new genetic andor autoimmune causes of catatonia that may inform new treatment for future patients
Detailed Description:
Catatonia is a complex condition that affects childrens behavior movement and emotions It can be caused by various underlying health issues such as genetic disorders or problems with the immune system Identifying these underlying causes is crucial for providing the best care and treatment to affected children In this study we aim to compare the effectiveness of traditional medical tests with a more advanced approach that includes genetic testing and immune system screening in finding the underlying causes of catatonia in children We will compare two groups of children with catatonia One group will be identified from hospital records and will have undergone standard medical tests to find the cause of their catatonia The other group will be a new set of patients who will receive both standard medical tests and additional advanced testing including genome sequencing a technique that reads the entire genetic code and screening for antibodies that attack the brain We will use a statistical method called propensity score matching to make sure that the two groups are as similar as possible in terms of age sex and other relevant factors This will help us to fairly compare the effectiveness of the two approaches in identifying the underlying causes of catatonia We expect that combining standard medical tests with genome sequencing and autoantibody screening will be more effective in finding the underlying causes of catatonia in children compared to using standard medical tests alone This could lead to more accurate diagnoses and more targeted treatments for children with catatonia helping them to recover more quickly and improving their quality of life If our study shows that the advanced testing approach is more effective in finding the underlying causes of catatonia this could change the way doctors approach the diagnosis and treatment of this complex condition In turn this could lead to more accurate diagnoses tailored treatments and improved outcomes for children with catatonia and their families
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None