Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06656104
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-15
Brief Title:
Impact of a Multi-infusion Strategy in Neonatology on the Rate of Central Line-associated Bloodstream Infections
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Impact of a Multi-infusion Strategy in Neonatology on the Rate of Central Line-associated Bloodstream Infections
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EDELVAISS
Brief Summary:
The management of premature infants hospitalized in neonatal units requires the simultaneous intravenous IV infusion of several drugs and parenteral nutrition solutions when oral administration is impossible or unsuitable IV administration requires the use of a central venous catheter and an infusion set that connects the catheter to the infusion fluid or drug The use of multiple infusion devices exposes patients to central line-associated bloodstream infections CLABSI drug interactions abnormal administration timing and repetition of procedures in close proximity to the infant
Against this backdrop DORAN INTERNATIONAL has developed the EDELVAISS multi-infusion strategy Multiline Neo and Escape Line devices adapted to neonatology Given its characteristics the benefits expected from the use of this strategy are 1 to reduce the risk of microbial contamination and therefore the number of nosocomial infections 2 reduce exposure to antibiotics used in late sepsis 3 reduce the number of central line losses due to catheter obstruction 4 reduce dys-stimulating procedures in contact with the infant and 5 reduce staff stress
A pilot study before year 2019 and after year 2020 was carried out in the tertiary care neonatal unit at Croix-Rousse hospital The baseline CLABSI rate was slightly below the national level of the last French survey 1241000 catheter days 95CI108140 In 322 very-low-birth-weight infants the investigators showed a significant 88 reduction in the rate of catheter-related bacteremia from 113 to 22 infections per 1000 catheter-days after implementation of the EDELVAISS multi-infusion strategy
Since this pilot study the EDELVAISS multi-infusion strategy has been used routinely in the neonatology department for around 2000 infants admitted to the neonatology department at Croix-Rousse hospital The low CLABSI rate observed in 2020 was maintained over the following 2 years Several tertiary care neonatology departments have implemented the EDELVAISS multi-infusion strategy ten departments have already done so and five are in the process of doing so The three neonatal units that agreed to take part in the EDELVAISS study also wish to implement the EDELVAISS multi-infusion strategy
The invetsigators hypothesize that the reduction in CLABSI rates observed in the neonatal unit at Croix-Rousse hospital during the pilot study will be found in other French neonatal units whatever the initial practices and devices used in each center
Against this backdrop DORAN INTERNATIONAL has developed the EDELVAISS multi-infusion strategy Multiline Neo and Escape Line devices adapted to neonatology Given its characteristics the benefits expected from the use of this strategy are 1 to reduce the risk of microbial contamination and therefore the number of nosocomial infections 2 reduce exposure to antibiotics used in late sepsis 3 reduce the number of central line losses due to catheter obstruction 4 reduce dys-stimulating procedures in contact with the infant and 5 reduce staff stress
A pilot study before year 2019 and after year 2020 was carried out in the tertiary care neonatal unit at Croix-Rousse hospital The baseline CLABSI rate was slightly below the national level of the last French survey 1241000 catheter days 95CI108140 In 322 very-low-birth-weight infants the investigators showed a significant 88 reduction in the rate of catheter-related bacteremia from 113 to 22 infections per 1000 catheter-days after implementation of the EDELVAISS multi-infusion strategy
Since this pilot study the EDELVAISS multi-infusion strategy has been used routinely in the neonatology department for around 2000 infants admitted to the neonatology department at Croix-Rousse hospital The low CLABSI rate observed in 2020 was maintained over the following 2 years Several tertiary care neonatology departments have implemented the EDELVAISS multi-infusion strategy ten departments have already done so and five are in the process of doing so The three neonatal units that agreed to take part in the EDELVAISS study also wish to implement the EDELVAISS multi-infusion strategy
The invetsigators hypothesize that the reduction in CLABSI rates observed in the neonatal unit at Croix-Rousse hospital during the pilot study will be found in other French neonatal units whatever the initial practices and devices used in each center
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None