Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06653283
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-19
Brief Title:
Application of Multiparametric Structural and Functional MRI in Unraveling the Substrates of Cognitive Impairment and Disability in Multiple Sclerosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Application of Multiparametric Structural and Functional MRI in Unraveling the Substrates of Cognitive Impairment and Disability in Multiple Sclerosis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MS MRI
Brief Summary:
Multiple sclerosis MS is a disabling inflammatory demyelinating disease of the nervous system that predominantly affects white matter because of its complicated pathogenesis and overlapping clinical manifestations with other inflammatory demyelinating diseases diseases which compromises clinical diagnosis and assessment for some patients at an early stage leading to delayed treatment Therefore the development and validation of simple non-invasive accurate biomarkers becomes an urgent need Neurite orientation dispersion and density imaging NODDI is an advanced diffusion model applied to quantify the extent of neurite destruction allowing early assessment of the integrity of brain white matter microstructure Many previous studies have shown that diffusion tensor imaging DTI can reflect the damage caused by MS but it cannot accurately describe the true course of fiber bundles such as curved and crossed fiber bundles In addition most of the studies are cross-sectional and lack of longitudinal follow-up In this study NODDI technique was used to investigate the damage pattern of white matter microstructural integrity in the early stage of multiple sclerosis for early diagnosis and differential diagnosis In addition to evaluate the relationship between NODDI parameters and clinical disability and cognitive impairment in MS reveal the relationship between the pattern of white matter microstructural integrity damage and the severity of the disease to improve the understanding of the pathophysiological mechanisms of clinical disability and cognitive impairment and provide potential therapeutic targets To search for imaging biomarkers that can assesspredict disability progression and cognitive deterioration in patients with MS Based on the above results we can then propose a comprehensive and individualized model for the initial diagnosis progression and clinical prognosis in patients with MS
Detailed Description:
Multiple sclerosis MS is a disabling inflammatory demyelinating disease of the nervous system that predominantly affects white matter because of its complicated pathogenesis and overlapping clinical manifestations with other inflammatory demyelinating diseases diseases which compromises clinical diagnosis and assessment for some patients at an early stage leading to delayed treatment Therefore the development and validation of simple non-invasive accurate biomarkers becomes an urgent need Neurite orientation dispersion and density imaging NODDI is an advanced diffusion model applied to quantify the extent of neurite destruction allowing early assessment of the integrity of brain white matter microstructure Many previous studies have shown that diffusion tensor imaging DTI can reflect the damage caused by MS but it cannot accurately describe the true course of fiber bundles such as curved and crossed fiber bundles In addition most of the studies are cross-sectional and lack of longitudinal follow-up In this study NODDI technique was used to investigate the damage pattern of white matter microstructural integrity in the early stage of multiple sclerosis for early diagnosis and differential diagnosis In addition to evaluate the relationship between NODDI parameters and clinical disability and cognitive impairment in MS reveal the relationship between the pattern of white matter microstructural integrity damage and the severity of the disease to improve the understanding of the pathophysiological mechanisms of clinical disability and cognitive impairment and provide potential therapeutic targets To search for imaging biomarkers that can assesspredict disability progression and cognitive deterioration in patients with MS Based on the above results we can then propose a comprehensive and individualized model for the initial diagnosis progression and clinical prognosis in patients with MS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None