Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06653205
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-20
Brief Title:
Prediction of Acute Pancreatitis Outcome
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Systemic Inflammation Response Index and Systemic Immune Inflammation Index and Prediction of Clinical Outcome in Acute Pancreatitis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aim of study prediction of acute pancreatitis outcome by using cheap and available laboratory resources
Detailed Description:
Acute pancreatitis AP is a sudden inflammation of the pancreas that can vary from mild self-resolving episodes to severe potentially fatal conditions1 Clinically AP is classified into mild acute pancreatitis and severe acute pancreatitis SAP and SAP patients are described by multi-organ failure and high mortality rates2 The mortality rate of acute pancreatitis varies ranging from 3 in cases of mild edematous pancreatitis to as high as 20 in patients with pancreatic necrosis3The progression of AP can lead to systemic complications making early prediction of clinical outcomes essential for effective management4
In recent years there has been growing interest in identifying reliable biomarkers that can predict the severity and outcomes of acute pancreatitis5 Systemic inflammation is a key factor in the pathophysiology of acute pancreatitis often leading to systemic inflammatory response syndrome SIRS and subsequent organ dysfunction6 Consequently assessing systemic inflammation has become a crucial aspect of managing AP patients7
The Systemic Inflammation Response Index SIRI is recognized in the literature as an inflammatory marker that combines routine blood parameters such as neutrophils monocytes and lymphocytes8 Both SIRI and the Systemic Immune Inflammation Index SII are emerging as novel biomarkers for systemic inflammation9 SIRI is calculated using neutrophil monocyte and lymphocyte counts while SII is based on platelet neutrophil and lymphocyte counts10
In recent years there has been growing interest in identifying reliable biomarkers that can predict the severity and outcomes of acute pancreatitis5 Systemic inflammation is a key factor in the pathophysiology of acute pancreatitis often leading to systemic inflammatory response syndrome SIRS and subsequent organ dysfunction6 Consequently assessing systemic inflammation has become a crucial aspect of managing AP patients7
The Systemic Inflammation Response Index SIRI is recognized in the literature as an inflammatory marker that combines routine blood parameters such as neutrophils monocytes and lymphocytes8 Both SIRI and the Systemic Immune Inflammation Index SII are emerging as novel biomarkers for systemic inflammation9 SIRI is calculated using neutrophil monocyte and lymphocyte counts while SII is based on platelet neutrophil and lymphocyte counts10
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None