Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06650111
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-17
Brief Title:
Epidemiology Diagnosis Medical Care and Prognosis of Tubulointerstitial Nephritis Results of a Multicenter Retrospective Cohort Study
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Epidemiology Diagnosis Medical Care and Prognosis of Tubulointerstitial Nephritis Results of a Multicenter Retrospective Cohort Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NETI-MULTI
Brief Summary:
Tubulointerstitial nephritis TIN diagnosed on kidney biopsy represents a common cause of kidney failure The etiologies are multiple but the diagnosis of the causative disease is sometimes difficult and the treatment is not completely codified
The research focuses on the characterization of TIN on the etiological clinical biological therapeutic and prognostic levels in order to improve patient care
For this purpose kidney biopsies performed for the diagnosis kept in a biological collection within the biological resource platforms of the Necker-Enfants Malades hospital and the Georges Pompidou hospital will be centrally reviewed blinded to the final diagnosis
The research focuses on the characterization of TIN on the etiological clinical biological therapeutic and prognostic levels in order to improve patient care
For this purpose kidney biopsies performed for the diagnosis kept in a biological collection within the biological resource platforms of the Necker-Enfants Malades hospital and the Georges Pompidou hospital will be centrally reviewed blinded to the final diagnosis
Detailed Description:
Tubulointerstitial nephritis TIN is defined as a diverse set of renal pathologies caused by a primary lesion of the interstitial compartment which most often extends to the associated tubular structures Renal histology establishes the diagnosis by objectifying different types of lesions associated to varying degrees depending on the etiology and clinical course These lesions are an interstitial inflammatory infiltrate whose nature is largely dependent on the etiopathogenic mechanisms of the lesion diffuse or multifocal interstitial fibrosis tubular epithelial lesions in the form of tubulitis andor tubular atrophy
Research focuses on the characterization of TIN on the etiological clinical biological therapeutic and prognostic levels in order to try to improve patient care For this
1st step native kidney biopsies performed to establish the diagnosis and kept in a biological collection within the biological resource platforms of the Necker-Enfants Malades hospital and the Georges Pompidou hospital will be centrally reviewed The review will be performed at the Pathology department of Necker hospital blinded to the final diagnosis for selection of the biopsies that will be included in the study Included biopsies will be those with tubulointerstitial nephritis retained as the main cause of renal dysfunction after etiological investigation
2nd step collection of clinical and biological data regarding the diagnosis management and prognosis
3rd step statistical analysis of the data and consolidation of the results
Research focuses on the characterization of TIN on the etiological clinical biological therapeutic and prognostic levels in order to try to improve patient care For this
1st step native kidney biopsies performed to establish the diagnosis and kept in a biological collection within the biological resource platforms of the Necker-Enfants Malades hospital and the Georges Pompidou hospital will be centrally reviewed The review will be performed at the Pathology department of Necker hospital blinded to the final diagnosis for selection of the biopsies that will be included in the study Included biopsies will be those with tubulointerstitial nephritis retained as the main cause of renal dysfunction after etiological investigation
2nd step collection of clinical and biological data regarding the diagnosis management and prognosis
3rd step statistical analysis of the data and consolidation of the results
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None