Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06649253
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-15
Brief Title:
Childhood B-acute Lymphoblastic Leukaemia and Role of CD9 Gene Regulation in Relapse
Sponsor:
None
Organization:
None
Study Overview
Official Title:
REALL CD9 Molecular Mechanisms Involved in Relapses of Childhood B-acute Lymphoblastic Leukaemia Role of Non-coding RNA in CD9 Gene Regulation
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
REALL CD9
Brief Summary:
B-acute lymphoblastic leukaemia B-ALL is the most common cancer in children with 20 of patients relapsing CD9 a transmembrane protein is linked to the migratory and adhesion capacities of leukaemia cells and could be associated with relapses The aim of this project is to understand how CD9 regulation can be a marker of potential relapses using bone and blood sampling of newly diagnosed patients at 3 crucial moments of therapy
Detailed Description:
B-acute lymphoblastic leukaemia B-ALL is the most common cancer in children with 20 of patients relapsing despite major therapeutic advances A research team of the Development and Genetic Institute in Rennes has identified that the expression of CD9 a transmembrane protein is linked to the migratory and adhesion capacities of leukaemia cells enabling them to persist in niches such as the testis CD9-associated relapses often arise from these niches Understanding the regulation of CD9 expression is therefore essential
The hypothesis on which this project is based is that CD9 expression could be orchestrated by ncRNAs Due to the complexity of deciphering circRNA-miRNA-mRNA networks an exploration of patient blasts is envisaged in order to delineate a specific non-coding RNA network regulating CD9 expression from bone marrow and blood samples of paediatric-aged patients with B-ALL If this hypothesis is confirmed the ncRNAs identified could constitute new specific diagnostic and prognostic markers or even therapeutic targets
To confirm this hypothesis bone and blood sampling of newly diagnosed patients will be collected at the diagnosis after first phase of treatment and at the relapse if it occurs
The hypothesis on which this project is based is that CD9 expression could be orchestrated by ncRNAs Due to the complexity of deciphering circRNA-miRNA-mRNA networks an exploration of patient blasts is envisaged in order to delineate a specific non-coding RNA network regulating CD9 expression from bone marrow and blood samples of paediatric-aged patients with B-ALL If this hypothesis is confirmed the ncRNAs identified could constitute new specific diagnostic and prognostic markers or even therapeutic targets
To confirm this hypothesis bone and blood sampling of newly diagnosed patients will be collected at the diagnosis after first phase of treatment and at the relapse if it occurs
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None