Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06646094
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-11
Brief Title:
Assessment of Cognitive Functions in Patients Receiving Whole Brain Radiotherapy in Assiut University Hospitals
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Assessment of Cognitive Functions in Patients Receiving Whole Brain Radiotherapy in Assiut University Hospitals
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Whole Brain Radiotherapy WBRT is widely used to manage brain metastases and primary brain tumors but it frequently leads to cognitive decline affecting patients quality of life Cognitive impairments after WBRT can manifest in various domains including memory attention executive function and processing speed These changes are attributed to direct radiation damage to neural tissues particularly the hippocampus and white matter tracts as well as secondary effects such as inflammation and vascular injury Existing literature reports that up to 30 of patients may experience significant cognitive deterioration after WBRT with the degree of impairment influenced by factors like total radiation dose fractionation schedule patient age and baseline cognitive function Despite these concerns there is currently no standardized protocol for assessing cognitive changes in patients undergoing WBRT Hippocampal avoidance and neuroprotective agents like memantine have shown potential in mitigating cognitive side effects but their implementation remains inconsistent Furthermore routine cognitive assessments are not yet part of standard clinical practice leading to a reactive rather than proactive approach to managing cognitive decline This gap in early detection and standardized cognitive monitoring highlights the need for better methods to understand and manage the cognitive consequences of WBRT Without systematic assessment cognitive impairments may go unrecognized until they significantly impact daily functioning emphasizing the importance of addressing this issue to better support patients undergoing whole brain radiotherapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None