Ignite Creation Date:
2024-10-26 @ 3:43 PM
Last Modification Date:
2024-10-26 @ 3:43 PM
Study NCT ID:
NCT06645340
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-10-15
Brief Title:
Does Nicotine Influence the Risk of Preeclampsia
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Does Nicotine Influence the Risk of Preeclampsia A Prospective Study
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PRE_Smoking
Brief Summary:
This prospective cohort study explores the long-term impact of pre-pregnancy smoking on vascular health in women predisposed to preeclampsia conducted at the Medical University of Graz The study specifically targets women at high risk for preeclampsia who are taking aspirin as a preventative measure
The main question it aims to answer is
Does smoking before pregnancy influence the development and severity of preeclampsia and its associated vascular changes in high-risk women
Participants divided into former smokers and non-smokers underwent comprehensive assessments throughout their pregnancies Measurements included hemodynamic parameters such as heart rate and blood pressure assessed with an upper arm cuff and arterial stiffness evaluated using pulse wave velocity with the Vicorder device Retinal microvasculature was examined through digital imaging and the vascular health marker ADMA nicotine exposure marker cotinine blood pressure regulatory enzyme neprilysin and cellular aging indicator telomere length were quantified from blood samples Cortisol levels were also measured from hair samples to assess stress responses
The main question it aims to answer is
Does smoking before pregnancy influence the development and severity of preeclampsia and its associated vascular changes in high-risk women
Participants divided into former smokers and non-smokers underwent comprehensive assessments throughout their pregnancies Measurements included hemodynamic parameters such as heart rate and blood pressure assessed with an upper arm cuff and arterial stiffness evaluated using pulse wave velocity with the Vicorder device Retinal microvasculature was examined through digital imaging and the vascular health marker ADMA nicotine exposure marker cotinine blood pressure regulatory enzyme neprilysin and cellular aging indicator telomere length were quantified from blood samples Cortisol levels were also measured from hair samples to assess stress responses
Detailed Description:
The investigators collected extensive data on each participant including age BMI body mass index and medical history to understand their baseline health Routine laboratory tests were conducted to monitor the health status throughout the pregnancy Preeclampsia biomarkers and Doppler ultrasound examinations of the uterine and umbilical arteries to assess fetal and placental blood flow were conducted The investigators tracked the development of preeclampsia gestational hypertension GH and gestational diabetes mellitus GDM
Outcomes for the babies such as birth weight delivery method gender and the gestational week at delivery were meticulously recorded to evaluate the broader impacts of maternal smoking and vascular health on neonatal outcomes
Outcomes for the babies such as birth weight delivery method gender and the gestational week at delivery were meticulously recorded to evaluate the broader impacts of maternal smoking and vascular health on neonatal outcomes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None