Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06642324
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-12
Brief Title:
Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Exploration of Human Papillomavirus Association and Genomic Characteristics in Head and Neck Squamous Cell Carcinomas in Bangladesh
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HPV HNSCC
Brief Summary:
Head and neck squamous cell carcinoma HNSCC represents a significant public health burden in Bangladesh with a high incidence and mortality rate While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence the emergence of HPV-associated HNSCC presents a unique challenge The main goal of this observational study is to explore the prevalence risk factors and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population identify risk factors and any biologically driven mechanisms causing HNSCC
Detailed Description:
Head and neck squamous cell carcinoma HNSCC represents Bangladeshs significant public health challenge According to GLOBACAN data these cancers are among the most prevalent malignancies in the country with a considerable impact on morbidity and mortality rates Several factors contribute to the high incidence of HNSCC in Bangladesh including prevalent tobacco and betel nut chewing habits poor oral hygiene practices oncogenic viruses such as human papillomavirus HPV and limited access to healthcare facilities for early detection and treatment In recent years the incidence of HPV-associated HNSCC has been on the rise posing a significant health concern globally HPV16 and HPV18 have been strongly linked to the development of HNSCC The global surge of HPV-associated HNSCC necessitates further investigation particularly in regions like Bangladesh By addressing these critical areas this research has the potential to improve public health outcomes in Bangladesh significantly
The main goal of this observational study is to explore the prevalence risk factors and biological mechanisms underlying food habits and HPV-driven HNSCC in the Bangladeshi population Additionally the study aims to identify the gene expression changes related to these factors
At first the HNSCC samples will be detected through histopathology analysis followed by nucleic acid extraction from the carcinoma-positive samples Subsequently molecular screening will be conducted alongside an assessment of patient histories Based on the results from the molecular screening immunohistochemistry will be performed on both HPV-positive and HPV-negative HNSCC samples to assess carcinoma-related protein expression Finally a comprehensive cancer omics analysis will be conducted after obtaining the sequencing data Understanding these aspects is crucial for developing targeted prevention strategies including HPV vaccination campaigns and public health education initiatives on high-risk sexual behavior
The main goal of this observational study is to explore the prevalence risk factors and biological mechanisms underlying food habits and HPV-driven HNSCC in the Bangladeshi population Additionally the study aims to identify the gene expression changes related to these factors
At first the HNSCC samples will be detected through histopathology analysis followed by nucleic acid extraction from the carcinoma-positive samples Subsequently molecular screening will be conducted alongside an assessment of patient histories Based on the results from the molecular screening immunohistochemistry will be performed on both HPV-positive and HPV-negative HNSCC samples to assess carcinoma-related protein expression Finally a comprehensive cancer omics analysis will be conducted after obtaining the sequencing data Understanding these aspects is crucial for developing targeted prevention strategies including HPV vaccination campaigns and public health education initiatives on high-risk sexual behavior
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None