Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06639919
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-08
Brief Title:
Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of Membrane
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Investigation of Biochemical Changes in Maternal Blood as Well as Histological Changes in the Placenta and Amniotic Membrane of Pregnant Women Diagnosed With Preterm Premature Rupture of Membrane
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Although preterm premature rupture of membranes PPROM is one of the most common causes of preterm birth it can also lead to serious maternal and neonatal complications Although there are many known risk factors the cause is not fully understood Proteoglycans PG are macromolecules containing a core protein and at least one negatively charged polysaccharide glycosaminoglycan side chain and are expressed at high levels in the placenta Heparan sulfate proteoglycans HSPG represent a specific type of PG observed in the placenta Syndecans SDC are the main type of HSPG found in the placenta There are four types of syndecan a cell transmembrane PG syndecan-1 syndecan-2 syndecan-3 syndecan-4 By containing heparan sulfate and chondroitin sulfate chains syndecans interact specifically with a variety of ligands including vascular endothelial growth factor VEGF transforming growth factor-beta TGF-β and fibronectin all of which have important functions in the placenta They play a role in very important physiological processes including cell proliferation migration angiogenesis coagulation system and inflammation
The aim of this study is to biochemically and histologically investigate the relationship between maternal blood syndecan levels and PPROM and the relationship between postnatal syndecan levels in the amniotic membrane and placenta and PPROM
According to our literature review although there are studies on the presence of syndecan in the amnion and chorion and negative pregnancy outcomes there are no maternal syndecan blood levels or histopathological examinations regarding PPROM For this reason we predict that our study may pave the way for future studies aimed at preventing PPROM and its complications that may occur directly or indirectly We also think that it will be a pioneer for future studies
This prospective observational study was conducted by Manisa Celal Bayar University Department of Gynecology and Obstetrics The research will be conducted on pregnant women who voluntarily accept to participate in the study
Group 1 Pregnant women with PPROM n 14 Group 2 Control group pregnant women n 22 When the planned number of patients is reached sample collection will be terminated and biochemical and histological examinations will be performed
The aim of this study is to biochemically and histologically investigate the relationship between maternal blood syndecan levels and PPROM and the relationship between postnatal syndecan levels in the amniotic membrane and placenta and PPROM
According to our literature review although there are studies on the presence of syndecan in the amnion and chorion and negative pregnancy outcomes there are no maternal syndecan blood levels or histopathological examinations regarding PPROM For this reason we predict that our study may pave the way for future studies aimed at preventing PPROM and its complications that may occur directly or indirectly We also think that it will be a pioneer for future studies
This prospective observational study was conducted by Manisa Celal Bayar University Department of Gynecology and Obstetrics The research will be conducted on pregnant women who voluntarily accept to participate in the study
Group 1 Pregnant women with PPROM n 14 Group 2 Control group pregnant women n 22 When the planned number of patients is reached sample collection will be terminated and biochemical and histological examinations will be performed
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None