Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06639685
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-10
Brief Title:
Multi-parametric Functional MRI in Patients of Chronic Kidney Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Quantitative Mapping Based on Multi-parametric Functional MRI to Evaluate Renal Functions and Microstructure in Chronic Kidney Disease
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To explore the value of MR Fingerprinting-generated quantitative maps combined with ASL renal perfusion imaging in the assessment of renal impairment in chronic kidney disease
Detailed Description:
Chronic kidney disease CKD has become an important public health problem threatening human health worldwide The prevalence rate of CKD in Chinese adults is 108 but the awareness rate and diagnosis rate are generally low At present the assessment of renal impairment in CKD mainly relies on laboratory tests such as estimated glomerular filtration rate eGFR and urinary proteincreatinine ratio and the value of functional MRI in the assessment of renal impairment in patients with CKD is unclear As a new sequence still in the scientific research stage MR Fingerprinting can simultaneously generate quantitative T1 maps T2 maps and proton-weighted images in one breath holding scan with short scanning time high repeatability and accuracy It has been proved that quantitative techniques of T1 mapping and T2 mapping are valuable for evaluating the degree of renal fibrosis and water content Kidney is a blood-rich organ and the blood flow of kidney is of great significance to the evaluation of renal function ASL uses hydrogen protons in arterial blood as an endogenous tracer to evaluate tissue blood perfusion and can quantitatively evaluate renal blood perfusion in patients with CKD without the use of exogenous contrast agents avoiding the risk of aggravated renal damage and nephrogenic fibrosis caused by injection of gadoline-containing contrast agents The objective of our study was to explore the value of MRF sequence-generated quantitative maps combined with ASL renal perfusion imaging in the assessment of renal impairment in chronic kidney disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None