Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06639529
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-10-07
Brief Title:
Preliminary Study of CXCL3 As a Biomarker of Diabetic Kidney Disease
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Preliminary Study of CXCL3 As a Biomarker of Diabetic Kidney Disease
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to learn about CXCL3 as a biomarker for type 2 diabetic kidney disease DKD in adults between age of 18-80 The main question it aims to answer is
Is CXCL3 elevated in the serum or urine of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement
Is CXCL3 elevated in the mRNA of PBMC of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement
Is CXCL3 elevated in the kidney tissue of type 2 adult DKD patients compared to normal control or other glomerulonephritis Participants have already been diagnosed as DKD by renal biopsy
Is CXCL3 elevated in the serum or urine of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement
Is CXCL3 elevated in the mRNA of PBMC of type 2 adult DKD patients compared to normal control or diabetes mellitus without kidney involvement
Is CXCL3 elevated in the kidney tissue of type 2 adult DKD patients compared to normal control or other glomerulonephritis Participants have already been diagnosed as DKD by renal biopsy
Detailed Description:
Diabetic kidney disease DKD has become the first cause of end-stage renal disease The high cost of treatment brings a heavy burden to the social economy and medical insurance However the pathogenesis of DKD is still unclear Because the early symptoms of DKD are hidden and difficult to diagnose once a large amount of proteinuria occurs in clinical practice renal damage is often difficult to reverse and patients will soon enter ESRD Therefore it is of great social significance and economic benefits to clarify the pathogenesis of DKD and find more effective therapeutic targets for DKDIn our previous bioinformatics analysis it was found that CXCL3 was significantly increased in peripheral blood PBMC of DKD and CXCL3 was the core gene of DKD after screening by WGCNA and machine learning CXC legend 3 CXCL3 also known as GRO gamma GROγ is a 79 kDa protein composed of 73 amino acids CXCL3 is a member of the CXC subfamily of chemokines including the 39 ELR 39 motif of its receptor CXCR2 tuberculosis CXCL3 is considered to be a chemotactic factor for neutrophils while CXCL3 has other proven roles in the field of cancer Studies have shown that serum CXCL3 levels are associated with the progression and poor prognosis of colorectal cancer and CXCL3 overexpression increases the malignant behavior of tumor cells while down-regulation of its expression inhibits this phenomenon The CXCL3 released by macrophages can promote the transformation of fibroblasts into myofibroblasts thereby promoting the metastasis of pancreatic cancer However there are still few studies on CXCL3 in the kidney and its role in DKD needs to be further explored In the DKD single cell dataset and the KIT website we found that CXCL3 was significantly increased in DKD and was positively correlated with proteinuria and serum creatinine On the basis of previous bioinformatics analysis and verification this study further verified that the gene had no DKD damage in DKD and diabetes the mRNA expression level of peripheral blood PBMC in normal control and the expression level in serum and urine Elisa and further verified in kidney tissue animal and cell levels looking for new biomarkers for DKD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None