Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06638957
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-10-07
Brief Title:
Impact of the COVID-19 Pandemic on Oncologic Outcomes in Colorectal Cancer
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Impact of the Coronavirus Disease 2019 Pandemic on Oncologic Outcomes in Colorectal Cancer
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to assess the impact of the COVID-19 pandemic on colorectal cancer CRC outcomes particularly focusing on stage distribution and recurrence-free survival in patients undergoing surgery at eight tertiary care institutions in Korea from 2018 to 2020
Main Question Does the COVID-19 pandemic lead to more advanced stages of colorectal cancer at diagnosis and higher complication rates during surgery Is there a significant difference in recurrence-free survival between CRC patients treated before and during the pandemic
This study found that more patients presented with advanced-stage CRC during the COVID-19 pandemic with significantly higher rates of tumor-related complications perforations abscesses and preoperative obstructions as well as an increase in open surgeries and combined resections
No significant difference in recurrence-free survival was observed between the pre-COVID-19 and COVID-19 periods although postoperative complication rates were higher especially among rectal cancer patients and those receiving preoperative chemoradiotherapy
Main Question Does the COVID-19 pandemic lead to more advanced stages of colorectal cancer at diagnosis and higher complication rates during surgery Is there a significant difference in recurrence-free survival between CRC patients treated before and during the pandemic
This study found that more patients presented with advanced-stage CRC during the COVID-19 pandemic with significantly higher rates of tumor-related complications perforations abscesses and preoperative obstructions as well as an increase in open surgeries and combined resections
No significant difference in recurrence-free survival was observed between the pre-COVID-19 and COVID-19 periods although postoperative complication rates were higher especially among rectal cancer patients and those receiving preoperative chemoradiotherapy
Detailed Description:
This observational population-based cohort study was conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology guidelines It was approved by the regional ethics committee in the Republic of Korea and institutional review boards of the eight participating institutions Due to the anonymity of the data the requirement for informed consent was waived
The study timeline was determined by the phased social distancing measures implemented in the Republic of Korea in response to the COVID-19 pandemic The study focused on patients with CRC who underwent surgical treatment from 2018 to 2020 The pre-COVID-19 period extended from 2018 to February 2020 and the COVID-19 period began in March 2020 with the identification of the first COVID-19 case in the Republic of Korea and subsequent government measures to prevent the spread of the disease
Eight institutions across the Republic of Korea participated in the study including Asan Medical Center Seoul St Marys Hospital Korea University Anam Hospital Samsung Medical Center Pusan National University Yangsan Hospital Gangnam Severance Hospital Kyungpook National University Chilgok Hospital and Chonnam National University Hwasun Hospital These institutions are tertiary medical centers varying in location and size
The study timeline was determined by the phased social distancing measures implemented in the Republic of Korea in response to the COVID-19 pandemic The study focused on patients with CRC who underwent surgical treatment from 2018 to 2020 The pre-COVID-19 period extended from 2018 to February 2020 and the COVID-19 period began in March 2020 with the identification of the first COVID-19 case in the Republic of Korea and subsequent government measures to prevent the spread of the disease
Eight institutions across the Republic of Korea participated in the study including Asan Medical Center Seoul St Marys Hospital Korea University Anam Hospital Samsung Medical Center Pusan National University Yangsan Hospital Gangnam Severance Hospital Kyungpook National University Chilgok Hospital and Chonnam National University Hwasun Hospital These institutions are tertiary medical centers varying in location and size
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None