Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06638580
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-10-08
Brief Title:
Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome A Cross-Sectional Study
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome A Cross-Sectional Study
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This cross-sectional study aimed to investigate the retino-choroidal degenerative effects of periodontitis metabolic syndrome Mets and the combination of these diseases using optical coherence tomography OCT measurements Methods Ninety-two patients selected according to inclusion criteria were divided into 4 groups systemically and periodontally healthy Control systemically healthy periodontitis PD periodontally healthy metabolic syndrome MetS and periodontitis and metabolic syndrome combined PD-MetS The systemic inflammatory-oxidative effects of periodontitis and MetS were biochemically evaluated using serum TNF Tumor necrosis factor-α level ILInterleukin-1βIL-10 ratio and oxidative stress index OSI TOSTAS Retinal AMT peripapillary retinal nerve fiber layer thickness pRNFLT and Ganglion cell and Inner plexiform layers GCLT and choroidal SFCT morphometric measurements and vascular evaluations foveal capillary density were performed via OCT Angio with swept-source technology
To the best of our knowledge although there are many clinical studies on the possible effects of Mets on retino-choroidal layers there is a limited amount of evidence on the effects of periodontitis which is from an animal study Moreover there are no studies on the retinal degenerative effects of the combined presence of periodontitis and Mets In this context the present study is unique and based on the hypothesis that the alone or combined presence of periodontitis and Mets may provoke retino-choroidal degenerative changes through systemic inflammatory stress
To the best of our knowledge although there are many clinical studies on the possible effects of Mets on retino-choroidal layers there is a limited amount of evidence on the effects of periodontitis which is from an animal study Moreover there are no studies on the retinal degenerative effects of the combined presence of periodontitis and Mets In this context the present study is unique and based on the hypothesis that the alone or combined presence of periodontitis and Mets may provoke retino-choroidal degenerative changes through systemic inflammatory stress
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None