Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06629558
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-01
Brief Title:
Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Efficacy and Safety of 05 wv Nano- Silver Nitrate Versus Silver Nitrate Solution for Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema Prospective Interventional Randomized Controlled Clinical Trial
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease COPD poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement
In recent years bronchoscopic lung volume reduction BLVR has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema
BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents Many techniques are available for BLVR as coil endo-bronchial valve and biological as thrombin autologous blood and chemicals as silver nitrate solution
In recent years bronchoscopic lung volume reduction BLVR has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema
BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents Many techniques are available for BLVR as coil endo-bronchial valve and biological as thrombin autologous blood and chemicals as silver nitrate solution
Detailed Description:
Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease COPD poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement
In recent years bronchoscopic lung volume reduction BLVR has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema
BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents Many techniques are available for BLVR as coil endo-bronchial valve and biological as thrombin autologous blood and chemicals as silver nitrate solution
Chemical lung volume reduction is an endo-bronchial approach which uses chemical agents aiming to reduce lung volume by blocking off the most emphysematous areas with a rapidly polymerizing sealant Endobronchial Valves EBVs show an overall success rate of 70-80 in reducing lung volume and improving lung function Lung volume reduction coils LVRC-Coils have a success rate of 50-60
Bronchoscopic lung volume reduction with silver nitrate as a chemical agent was used in previous studies using a concentration of 05 and showed significant improvement in forced expiratory volume in first second FEV1 diffusion capacity of lung to carbon monoxide DLCo modified Medical Research Council mMRC score when compared to base line values and reduction of the High Resolution Computed Tomography HRCT volumetry of the emphysematous regions
Silver nanoparticles AgNPs are the most widely used nanomaterial today These have found a wide range of applications in various areas such as textiles agriculture renewable energy food catalysis bioremediation and biomedicine
In recent years bronchoscopic lung volume reduction BLVR has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema
BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents Many techniques are available for BLVR as coil endo-bronchial valve and biological as thrombin autologous blood and chemicals as silver nitrate solution
Chemical lung volume reduction is an endo-bronchial approach which uses chemical agents aiming to reduce lung volume by blocking off the most emphysematous areas with a rapidly polymerizing sealant Endobronchial Valves EBVs show an overall success rate of 70-80 in reducing lung volume and improving lung function Lung volume reduction coils LVRC-Coils have a success rate of 50-60
Bronchoscopic lung volume reduction with silver nitrate as a chemical agent was used in previous studies using a concentration of 05 and showed significant improvement in forced expiratory volume in first second FEV1 diffusion capacity of lung to carbon monoxide DLCo modified Medical Research Council mMRC score when compared to base line values and reduction of the High Resolution Computed Tomography HRCT volumetry of the emphysematous regions
Silver nanoparticles AgNPs are the most widely used nanomaterial today These have found a wide range of applications in various areas such as textiles agriculture renewable energy food catalysis bioremediation and biomedicine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None