Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06629116
Status:
RECRUITING
Last Update Posted:
None
First Post:
2023-10-05
Brief Title:
Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy A Prospective Multicenter Open-label Endpoint-blinded Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project intends to explore the therapeutic efficacy of human serum albumin in mitigating postoperative cerebral edema and enhancing clinical outcomes following mechanical thrombectomy in patients with acute anterior circulation large-core ischemic stroke
Detailed Description:
Human serum albumin is an important biological molecule that plays a critical role in maintaining intracellular osmotic pressure combating oxidative stress and suppressing inflammatory responses Studies have indicated that serum albumin levels gradually decrease in acute-phase stroke patients accompanied by increased blood-brain barrier disruption Low albumin levels may exacerbate the progression of cerebral infarction Furthermore another study found a correlation between serum albumin levels and the prognosis of AIS Research has confirmed that human serum albumin may have potential benefits in neuroprotection through mechanisms such as improving microcirculation reducing oxidative stress and inhibiting inflammatory responses
In an experimental animal study of ischemic stroke researchers discovered that in the middle cerebral artery occlusion MCAO model rats treated with albumin showed significantly reduced neurological function scores and infarct volume compared to the saline group The mechanism behind this effect may be related to albumins ability to improve ischemic penumbral blood flow and enhance perfusion in occluded vessels distal regions Multiple preclinical studies have suggested that using albumin therapy after vascular recanalization can significantly reduce infarct volume alleviate brain edema and improve neurological function highlighting the neuroprotective role of serum albumin However the clinical efficacy of serum albumin in ischemic stroke remains a subject of controversy
The aim of this study is to investigate the role of human serum albumin in acute anterior circulation large core ischemic stroke after thrombectomy reperfusion with the hope of providing new insights and methods for clinical treatment This study will employ a prospective multicenter open-label endpoint-blinded randomized controlled research design to systematically evaluate the therapeutic effects of human serum albumin in acute anterior circulation large core ischemic stroke after thrombectomy reperfusion Through clinical observation imaging assessment neurofunctional evaluation and other methods the investigators will delve into the intervention of human serum albumin in reperfusion injury and its mechanisms in neuroprotection This research is expected to offer new perspectives and methods for the treatment of patients with acute anterior circulation large core ischemic stroke provide scientific evidence for clinical practice and contribute positively to improving patient outcomes and reducing the societal burden
In an experimental animal study of ischemic stroke researchers discovered that in the middle cerebral artery occlusion MCAO model rats treated with albumin showed significantly reduced neurological function scores and infarct volume compared to the saline group The mechanism behind this effect may be related to albumins ability to improve ischemic penumbral blood flow and enhance perfusion in occluded vessels distal regions Multiple preclinical studies have suggested that using albumin therapy after vascular recanalization can significantly reduce infarct volume alleviate brain edema and improve neurological function highlighting the neuroprotective role of serum albumin However the clinical efficacy of serum albumin in ischemic stroke remains a subject of controversy
The aim of this study is to investigate the role of human serum albumin in acute anterior circulation large core ischemic stroke after thrombectomy reperfusion with the hope of providing new insights and methods for clinical treatment This study will employ a prospective multicenter open-label endpoint-blinded randomized controlled research design to systematically evaluate the therapeutic effects of human serum albumin in acute anterior circulation large core ischemic stroke after thrombectomy reperfusion Through clinical observation imaging assessment neurofunctional evaluation and other methods the investigators will delve into the intervention of human serum albumin in reperfusion injury and its mechanisms in neuroprotection This research is expected to offer new perspectives and methods for the treatment of patients with acute anterior circulation large core ischemic stroke provide scientific evidence for clinical practice and contribute positively to improving patient outcomes and reducing the societal burden
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None