Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06629064
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-02
Brief Title:
Cognitive Control Training for Extinction in PTSD
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Identifying Clinically Relevant Neural Circuit Mechanisms of Cognitive Control Training for PTSD
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The proposed study will test whether a working memory training WMT program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder PTSD WMT is designed to improves the ability to maintain task-relevant information in mind The project will further validate the relationship between working memory and fear extinction using novel computational and multivariate analyses that link to specific PTSD symptoms If WMT can enhance fear extinction learning then WMT may be a powerful adjunctive treatment that can enhance exposure therapy outcomes or be leveraged as a stand-alone treatment This project supports the Department of Veteran Affairs mission of developing viable targets of treatment for Veterans with PTSD
Detailed Description:
Posttraumatic stress disorder PTSD is prevalent debilitating and associated with significant levels of functional impairment in Veterans seeking care at the VA Despite evidence that current treatments for PTSD are effective a substantial portion of individuals maintain elevated PTSD symptoms after first line treatments Mechanistic insight and tools that improve the neurocognitive and affective mechanisms that underlie successful clinical outcomes from evidence-based psychotherapies like prolonged exposure are highly needed One of the most prominent mechanisms associated with therapeutic symptom reduction in PTSD is fear extinction Indeed extinction learning is a key theoretical treatment target in exposure-based therapies for PTSD Fear extinction learning is not only an emotional process but relies on an individuals cognitive control abilities including working memory WM Under a WM framework high WM ability offers the ability of an individual to adjudicate the competition between threat and extinction memory expression as they repeatedly encounter feared cues that are no longer threatening Consistent with this hypothesis previous investigations show replicable findings that variation in WM ability is associated with laboratory measures of fear extinction learning The investigators have previously shown that psychophysiological and neural measures of fear extinction is a construct malleable to treatment In civilian populations a brief WM training WMT designed to boost WM was effective in reducing anxiety during a speech exposure and was is effective in enhancing behavioral and neural markers of WM ability These findings raise the intriguing possibility for the mechanistic link between WM and extinction and that enhancing WM ability through WMT may also improve fear extinction learning success in Veterans with PTSD
The current proposal aims to answer these questions In a between-group design Veterans diagnosed with PTSD will complete 8-sessions of working memory training WMT or sham-training ST over a four-week period At pre- and post-training Veterans will complete a standard fear acquisition extinction learning task in addition to tasks assaying WM capacity and cognitive control The investigators will identify whether WMT modulates behavior psychophysiological and neural changes in extinction learning The investigators will further test the conceptual link between WM and extinction in Veterans with PTSD by testing whether neural circuits associated with high WM capacity and extinction learning are linked The project is expected to determine if a cognitive control training program targeting WM capacity shows the potential to enhance behavioral and neural markers of fear extinction mechanisms that are clearly integral to current PTSD treatments These aims support the VA mission of testing and evaluating innovative treatment targets for PTSD Results will provide a mechanistic foundation for future clinical trials that test whether adding WMT prior to or in conjunction with exposure based psychotherapies will improve clinical outcomes and further clarify existing mechanistic and neurobiological models of PTSD and its treatment for Veterans
The current proposal aims to answer these questions In a between-group design Veterans diagnosed with PTSD will complete 8-sessions of working memory training WMT or sham-training ST over a four-week period At pre- and post-training Veterans will complete a standard fear acquisition extinction learning task in addition to tasks assaying WM capacity and cognitive control The investigators will identify whether WMT modulates behavior psychophysiological and neural changes in extinction learning The investigators will further test the conceptual link between WM and extinction in Veterans with PTSD by testing whether neural circuits associated with high WM capacity and extinction learning are linked The project is expected to determine if a cognitive control training program targeting WM capacity shows the potential to enhance behavioral and neural markers of fear extinction mechanisms that are clearly integral to current PTSD treatments These aims support the VA mission of testing and evaluating innovative treatment targets for PTSD Results will provide a mechanistic foundation for future clinical trials that test whether adding WMT prior to or in conjunction with exposure based psychotherapies will improve clinical outcomes and further clarify existing mechanistic and neurobiological models of PTSD and its treatment for Veterans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None