Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06628531
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-29
Brief Title:
ALI Pulmonary HA Deposition After SAH
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Relationship Between Acute Lung Injury and Pulmonary Hyaluronic Acid Deposition After Subarachnoid Hemorrhage
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute lung injury is a common complication of subarachnoid hematoma SAH and a significant risk factor for death in patients with SAH Unlike neurogenic pulmonary edema and pneumonia following brain injury the clinical causes of pulmonary injury after SAH are not intracranial hypertension or pulmonary infection Its occurrence is influenced by the release of catecholamines the regulatory function of the hypothalamic-pituitary-adrenal HPA axis and systemic inflammatory response but the specific mechanisms are still unclear Therefore delving into the pathological mechanisms of SAH-induced lung injury and developing therapeutic strategies based on the findings is of great importance to improve the prognosis of patients
Abnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases such as chest trauma pulmonary infection and chronic obstructive pulmonary disease From this the present research is aimed to explore the levels and dynamic changes of hyaluronic acid in the bronchoalveolar lavage fluid and blood of patients with acute lung injury following SAH and to analyze its correlation with the prognosis of pulmonary complications thereby providing assistance for the clinical diagnosis and treatment of SAH
Abnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases such as chest trauma pulmonary infection and chronic obstructive pulmonary disease From this the present research is aimed to explore the levels and dynamic changes of hyaluronic acid in the bronchoalveolar lavage fluid and blood of patients with acute lung injury following SAH and to analyze its correlation with the prognosis of pulmonary complications thereby providing assistance for the clinical diagnosis and treatment of SAH
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None