Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06628076
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-26
Brief Title:
Antibacterial Effect of Zinc Oxide Nanoparticles on Acinetobacter Baumannii Isolated from Patients with Hospital Acquired Infections in Sohag University Hospitals Egypt
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Antibacterial Effect of Zinc Oxide Nanoparticles on Acinetobacter Baumannii Isolated from Patients with Hospital Acquired Infections in Sohag University Hospitals Egypt
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
A baumannii is known as the most frequently isolated organism in intensive care units ICUs causing a variety of nosocomial infections including pneumonia urinary tract infections UTIs bacteremia as well as skin and soft tissue infections These infections are usually associated with high mortality rates ranging between 26 among hospitalized patients and 43 among ICU patients
Detailed Description:
Acinetobacter baumannii A baumannii is Gram- negative aerobic glucose non-fermentative non-motile coccobacillus ubiquitous in nature and persistent in healthcare settings It is regarded as a significant opportunistic human pathogen
This bacterium become a growing problem in hospitals as a predominant multidrug-resistant MDR bacterium Horizontal acquisition of resistance genes is the main factor involved in the emergence of MDR
There are many mechanisms to confer resistance to different classes of antibiotics in A baumannii one of them is multidrug efflux pumps These efflux pumps are important source of MDR which export antibiotics from the cell increasing their antibiotic resistance
AdeABC is one of the most important efflux systems belonging to the RND family in Acinetobacter which plays an important role in the resistance to a broad group of antibiotics its genes are chromosomal and encode three genes ie AdeB AdeA and AdeC forming an operon in the vicinity In addition the expression of AdeABC is done by a two-component system which includes a response regulator AdeR and a sensor kinase AdeS
The ability of Acinetobacter spp to form biofilm that enables bacterial survival in hospital settings especially in ICUs is the most significant contributing factor to their virulence and this trait is also responsible for their notable antibiotic resistance Several biofilm-related genes influence antimicrobial susceptibility suggesting an association between the biofilm-forming ability of Acinetobacter spp and their antibiotic resistance patterns MDRXDR
Zinc oxide nanoparticles ZnO NPs are one of the most important nanoparticles of metal oxides it is a unique and inorganic materials that can be used in several biological applications anti-bacterial anti-inflammatory ZnO NPs exhibit distinctive properties other than other nanoparticles such as higher solubility better biofilm penetration and effective drug delivery ZnO NPs have been reported to have antimicrobial properties such as disrupting the cell membrane of pathogens accumulating in the cell and producing toxic H2O2 hydrogen peroxide
This bacterium become a growing problem in hospitals as a predominant multidrug-resistant MDR bacterium Horizontal acquisition of resistance genes is the main factor involved in the emergence of MDR
There are many mechanisms to confer resistance to different classes of antibiotics in A baumannii one of them is multidrug efflux pumps These efflux pumps are important source of MDR which export antibiotics from the cell increasing their antibiotic resistance
AdeABC is one of the most important efflux systems belonging to the RND family in Acinetobacter which plays an important role in the resistance to a broad group of antibiotics its genes are chromosomal and encode three genes ie AdeB AdeA and AdeC forming an operon in the vicinity In addition the expression of AdeABC is done by a two-component system which includes a response regulator AdeR and a sensor kinase AdeS
The ability of Acinetobacter spp to form biofilm that enables bacterial survival in hospital settings especially in ICUs is the most significant contributing factor to their virulence and this trait is also responsible for their notable antibiotic resistance Several biofilm-related genes influence antimicrobial susceptibility suggesting an association between the biofilm-forming ability of Acinetobacter spp and their antibiotic resistance patterns MDRXDR
Zinc oxide nanoparticles ZnO NPs are one of the most important nanoparticles of metal oxides it is a unique and inorganic materials that can be used in several biological applications anti-bacterial anti-inflammatory ZnO NPs exhibit distinctive properties other than other nanoparticles such as higher solubility better biofilm penetration and effective drug delivery ZnO NPs have been reported to have antimicrobial properties such as disrupting the cell membrane of pathogens accumulating in the cell and producing toxic H2O2 hydrogen peroxide
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None