Ignite Creation Date:
2024-10-26 @ 3:42 PM
Last Modification Date:
2024-10-26 @ 3:42 PM
Study NCT ID:
NCT06626685
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-10-02
Brief Title:
Clonal Hematopoiesis of Indeterminate Potential in Heart Failure
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Clonal Hematopoiesis of Indeterminate Potential in Heart Failure - RICO-HF
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RICO-HF
Brief Summary:
This study is part of the Rico Macro-Project a multidisciplinary research program promoted by FROM in collaboration with the ASST-PG23 and ATS Bergamo aiming to investigate the role of clonal hematopoiesis on inflammation studying in depth the mechanisms underlying the inflammatory process to determine their correlation with some important pathologies in different clinical fields Hematology Cardiology Neurology Pneumology Gastroenterology and Diabetology etc In this context the prospective observational study RICO-HF is developed
The RICO HF is the first project focused on CHIP and inflammation in the area of Cardiology specifically in HF
The RICO HF is the first project focused on CHIP and inflammation in the area of Cardiology specifically in HF
Detailed Description:
CHIP is associated with a pro-inflammatory state and its mechanistic link to HF has been demonstrated in animal and cellular models and in patient cohorts 14-24
Although HF in humans has various causes different pathophysiological mechanisms and heterogeneous clinical manifestations the experimental and clinical data reported so far support the relevance of inflammatory cytokine production and signaling by immune cells in the pathogenesis of cardiac dysfunction and HF
Although HF in humans has various causes different pathophysiological mechanisms and heterogeneous clinical manifestations the experimental and clinical data reported so far support the relevance of inflammatory cytokine production and signaling by immune cells in the pathogenesis of cardiac dysfunction and HF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None