Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06625099
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-10-01
Brief Title:
Investigation of the Optimum PEEP Mechanical Power Relationship
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Comparison of the Effects of Different Positive Expiratory Pressure Levels on Patient Oxygenation and Mechanical Power Values in Laparoscopic Surgeries
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to compare the effects of standard and optimum positive end expiratory pressures on mechanical power during laparoscopic surgeries
Detailed Description:
Perioperative pulmonary complications and ventilator-associated lung injury are challenging issues for anesthesiologists especially after laparoscopic surgeries An increasing number of studies suggest lung protective ventilation LPV strategies in these patients It is recommended that patients39 driving pressure be kept low during LPV and positive expiratory pressure PEEP be applied to keep the lungs open However high PEEP values cannot be adequately applied in laparoscopic surgeries to reduce the restrictive peak pressure for LPV In laparoscopic surgeries the patient39s position and increased intra-abdominal pressure create pressure on the lungs However when the applied positive pressure ventilation is insufficient in patients it can cause atelectasis and when it is excessive it can cause barotrauma or volutrauma The threshold values determined for all these possible complications during LPV should be evaluated together 1
Gattinoni and colleagues 2016 explained the effect of mechanical ventilation on the lungs through a worktime formula and formulated the energy used during this work The applied energy is spent on opening the lungs and ventilation while the excess is consumed due to heat and resistance in the respiratory tract The unit of this energy can be formulated in a simplified way as joulesecond The mechanical power formula makes it easier to follow by providing a single parameter instead of different threshold values for barotrauma volutrauma and atelectrauma for the lungs Studies have shown that applying energy over 126 joules is associated with lung damage On the other hand the relationship between the optimum mechanical power MP value during ventilation and low and high PEEP is not yet fully known
In laparoscopic surgeries high PEEP application may help keep the lungs open and increase ventilation but it may cause higher mechanical power application In this case the effect of high PEEP application on ventilation and patient outcomes is unclear
In this study PEEP values and mechanical power values applied during ventilation in patients who will be operated under laparoscopic surgery will be monitored observationally and the PEEPMP relationship will be examined in terms of patient oxygenation
Gattinoni and colleagues 2016 explained the effect of mechanical ventilation on the lungs through a worktime formula and formulated the energy used during this work The applied energy is spent on opening the lungs and ventilation while the excess is consumed due to heat and resistance in the respiratory tract The unit of this energy can be formulated in a simplified way as joulesecond The mechanical power formula makes it easier to follow by providing a single parameter instead of different threshold values for barotrauma volutrauma and atelectrauma for the lungs Studies have shown that applying energy over 126 joules is associated with lung damage On the other hand the relationship between the optimum mechanical power MP value during ventilation and low and high PEEP is not yet fully known
In laparoscopic surgeries high PEEP application may help keep the lungs open and increase ventilation but it may cause higher mechanical power application In this case the effect of high PEEP application on ventilation and patient outcomes is unclear
In this study PEEP values and mechanical power values applied during ventilation in patients who will be operated under laparoscopic surgery will be monitored observationally and the PEEPMP relationship will be examined in terms of patient oxygenation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None