Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06624904
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-23
Brief Title:
Losartan and Social Processing
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Effects of Single-dose Losartan on Social Processing in Healthy Adults a Randomized Controlled Study
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study explores the effects of single-dose losartan 50mg versus placebo on social processing in healthy volunteers
Detailed Description:
While renin-angiotensin mechanisms have been implicated in physiological disease such as hypertension and stroke the discovery of a local brain renin-angiotensin system RAS in the 1970s brought into question whether the RAS may play a role in psychiatric disorders too Recent work has supported this link with several studies reporting RAS influence on aversive learning stress response to traumatic stimuli and fear extinction
Despite these promising results studies have yet to fully explore the influence of the RAS and losartan on social processes It is plausible that the RAS may be involved in social functioning as recent work reported that losartan reduces sensitivity to social punishment in healthy volunteers Such an effect of losartan may have broad relevance for psychopathology as impairment to social functioning is present across a range of psychiatric disorders
In this double-blind randomized between-group study the investigators will examine the effects of a single dose of losartan 50mg versus placebo on social processing in N58 healthy volunteers Following a one-hour waiting period participants will complete a set of computer tasks investigating social processes reported to be sensitive to psychopathology Specifically participants will complete the Approach Avoidance Task which assesses social approach and avoidance behaviour in response to various facial expressions via joystick movement the Interpretation Inflexibility Task which evaluates cognitive flexibility in a social context the Social Learning Trust Game which evaluates social learning through a trust game between participant investors and realistic trustees and Cyberball which probes response to social rejection Results from this study will provide more insight on the potential role of the RAS in social cognitive processing in humans which could lead to an improved mechanistic understanding of emotional disorders that are marked by social impairment
Despite these promising results studies have yet to fully explore the influence of the RAS and losartan on social processes It is plausible that the RAS may be involved in social functioning as recent work reported that losartan reduces sensitivity to social punishment in healthy volunteers Such an effect of losartan may have broad relevance for psychopathology as impairment to social functioning is present across a range of psychiatric disorders
In this double-blind randomized between-group study the investigators will examine the effects of a single dose of losartan 50mg versus placebo on social processing in N58 healthy volunteers Following a one-hour waiting period participants will complete a set of computer tasks investigating social processes reported to be sensitive to psychopathology Specifically participants will complete the Approach Avoidance Task which assesses social approach and avoidance behaviour in response to various facial expressions via joystick movement the Interpretation Inflexibility Task which evaluates cognitive flexibility in a social context the Social Learning Trust Game which evaluates social learning through a trust game between participant investors and realistic trustees and Cyberball which probes response to social rejection Results from this study will provide more insight on the potential role of the RAS in social cognitive processing in humans which could lead to an improved mechanistic understanding of emotional disorders that are marked by social impairment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None