Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06624488
Status:
RECRUITING
Last Update Posted:
None
First Post:
2024-09-30
Brief Title:
The Relationship Between Brain Injury Biomarkers in Cerebrospinal Fluid and Blood of Patients After Cardiac Arrest and Prognosis
Sponsor:
None
Organization:
None
Study Overview
Official Title:
The Relationship Between Brain Injury Biomarkers in Cerebrospinal Fluid and Blood of Patients After Cardiac Arrest and Prognosis
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is a single-center prospective observational study After successful cardiopulmonary resuscitation for patients with cardiac arrest they will be transferred to the emergency intensive care unit for further standardized targeted temperature management When evaluating that the patient meets the indications for lumbar puncture and there are no contraindications for lumbar puncture lumbar puncture examinations will be completed immediately after return of spontaneous circulation ROSC at 24 hours of hypothermia at 72 hours of hypothermia and after rewarming Routine cerebrospinal fluid examinations such as cerebrospinal fluid routine cerebrospinal fluid biochemistry and cerebrospinal fluid lactate will be sent for inspection At the same time 6 ml of cerebrospinal fluid will be retained and stored in a refrigerator at -80C After sample collection is completed enzyme-linked immunosorbent assay ELISA will be used to detect markers such as NSE HCH-L1 NFL tau MBP GFAP and S100β While performing the lumbar puncture examination peripheral blood will be collected After centrifugation for 10 minutes 4000 revolutions serum will be retained and stored in a refrigerator at -80C to complete the examination of the above markers After 3 months the patient39s neurological function prognosis will be followed up according to the Pittsburgh Cerebral Performance Category CPC scale
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None