Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06623591
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-30
Brief Title:
Ameliorating Effects and Mechanisms of TaVNS on Constipation in PD Patients
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Ameliorating Effects and Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation on Constipation in Parkinson39s Disease Patients a Randomized Double-blind Clinical Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators intend to conduct a randomized double-blind sham-stimulation-controlled experiment incorporating various clinical scales gastrointestinal electrogram and high-resolution anorectal manometry HRAM to investigate the improvement effect of taVNS on constipation symptoms in PD patients
Detailed Description:
The investigators intend to conduct a randomized double-blind sham-stimulation-controlled experiment incorporating various clinical scales gastrointestinal electrogram and high-resolution anorectal manometry HRAM to investigate the improvement effect of taVNS on constipation symptoms in PD patients Meanwhile the investigators aimed to verify mechanistic effects by investigating changes in proteins and cytokines related to inflammation and intestinal barrier function in serum and feces to verify mechanistic effects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None