Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06623344
Status:
NOT_YET_RECRUITING
Last Update Posted:
None
First Post:
2024-09-30
Brief Title:
Brain Volume and Cardiac Function in Heart Failure
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Brain Volume and Cardiac Function in Heart Failure
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with heart failure HF exhibit greater structural brain alterations and higher dementia risks than the general population Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients Reduction of cerebral blood flow has been suggested as the pathophysiological pathway linking HF and structural brain changes Indeed lower cardiac index levels were related to lower cerebral blood flow in older adults without stroke dementia or heart failure A few prior studies have examined the subcortical structural differences in patients with HF compared to controls Brain volume loss including putamen and hippocampal volumes have been reported in patients with low ejection fraction Significant gray matter loss was found in specific brain regions of HF patients and included structures that serve demonstrated roles in cognitive functions In the investigators previous study Comprehensive Imaging Exam of Convalesced COVID-19 Patients - COVID-19 RELATED SUBMISSION-IRB00252436 involving 100 participants volunteers with normal heart function ejection fraction 50 the investigators observed significant correlations between thalamic volumes and ventricular stroke volumes in volunteers Building on these findings the investigators intend to expand the research to include individuals with heart failure HF employing the same MRI protocol The study will involve obtaining a set of T1-weighted brain images to measure the volumes of seven subcortical structures The investigators goal is to explore the relationship between subcortical volumes and cardiac parameters Additionally the investigators will examine whether patients with HF experience a more rapid reduction in subcortical volumes compared to those with normal cardiac function EF50
Detailed Description:
Heart failure HF is a multifaceted clinical syndrome characterized by the hearts inability to effectively pump blood to meet the bodys demands This condition often results from various structural or functional cardiac disorders impacting not only the heart but also multiple organ systems including the brain kidneys lungs and circulatory system Patients with heart failure present a spectrum of symptoms that significantly affect quality of life such as dyspnea and fatigue and are typically identified by cardiac dysfunction markers like abnormal left or right ventricular filling and elevated filling pressures Recent advances in diagnostic technologies particularly in imaging modalities like Cardiovascular Magnetic Resonance Imaging CMR have opened new avenues for in-depth exploration of heart failures underlying pathophysiology CMR is increasingly used in heart failure management for risk stratification viability assessment and diagnosing conditions like myocarditis and cardiomyopathy This technology enables detailed assessment of myocardial function structural changes and interactions with other organ systems Patients with heart failure exhibit greater structural brain alterations and higher dementia risks than the general population Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients Initial research showed a strong correlation between thalamic volumes and ventricular stroke volumes in healthy volunteers The investigators plan to extend this study to heart failure HF patients using the same MRI methods to assess the connection between subcortical brain volumes and heart health Additionally the investigators will explore if HF patients experience a faster decline in these brain volumes than individuals with normal heart function
- Objectives
Primary To access the correlation of cardiac structure and function to the subcortical volumes in patients with heart failure
Secondary To compare the correlation between cardiac structure and function and subcortical volumes in heart failure patients with that in participants with normal heart function
- Objectives
Primary To access the correlation of cardiac structure and function to the subcortical volumes in patients with heart failure
Secondary To compare the correlation between cardiac structure and function and subcortical volumes in heart failure patients with that in participants with normal heart function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None