Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06622018
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-28
Brief Title:
Effect of Seashell Nanoparticles and Gluma Desensitizer on Sensitivity of Teeth
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Effect of Seashell Nanoparticles and Gluma Desensitizer on Sensitivity of Teeth Prepared for Intra Coronal Restorations as Well as Micromorphology of The Treated Dentin Surfaces
Status:
COMPLETED
Status Verified Date:
2023-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Tooth hypersensitivity is characterized by a transient short and sharp pain originating from exposed dentin in response to thermal dehydrating tactile osmotic and chemical stimuli Tooth sensitivity after cementation of complete coverage crowns is a rather common event since much of the protecting enamel is removed during preparation and a large area of dentin is exposed
Dentin contains up to two million tubules per cm2 which corresponds approximately to the surface area of most crown preparations It is well known that such dentin wounds respond to mechanical osmotic or thermal stimulation with pain This phenomenon is commonly example by the hydrodynamic theory of Brannstrom
Dentin contains up to two million tubules per cm2 which corresponds approximately to the surface area of most crown preparations It is well known that such dentin wounds respond to mechanical osmotic or thermal stimulation with pain This phenomenon is commonly example by the hydrodynamic theory of Brannstrom
Detailed Description:
The extent and duration of post cementation hypersensitivity has been related to number of factors mainly associated with preparation trauma However research reports confirm potential effects of luting agents used and leakage of bacteria and bacterial products from the oral cavity along the margins of restorations especially as a response to poorly fitting temporary restorations Apparently a relationship exists between the time interval during which the temporary restoration is in place and post cementation sensitivity
Gluma Desensitizer is a combination of glutaraldehyde and HEMA Hydroxy Ethyl Methacrylate Glutaraldehyde causes amino acids and proteins to coagulate in dentinal tubules and is an effective disinfectant HEMA can be effective in sealing of dentinal tubules
Gluma does not interfere with dentin bonding systems but its glutaraldehyde component can damage the gingiva after long term exposure HEMA can cause contact dermatitis and it can actually perforate latex gloves and must be used with caution hence the use of rubber dam is advised in such cases
HEMA is soluble in water allowing it to penetrate deep into dentinal tubules however the effect is reversible and HEMA gradually loses its effect allowing the dentinal tubules to again became exposed
Hydroxyapatite powder is one such material that exhibits excellent bioactive properties and striking similarities to dental hard tissues can be achieved from two different sources Synthetic and natural biologic hydroxyapatiteHAP can be produced from Coral Seashells eggshells and also from body fluids
Recently the use of waste materials to synthesize HAP has received great response from many researchers across the world This idea gives an innovation to produce a new valuable product from the waste materials such as seashellSeashell consists of high source of calcium that can act as calcium precursor Some researcher found that the content of calcium carbonate CaCO3 in seashell is approximately between 98 and 99
The word seashell is often used to mean only the shell of a marine mollusk Using seashell as source of calcium carbonate CaCO3 to produce calcite nanoparticle is meaningful for both environmental protection and biomedical application Seashell is with the natural ceramic structure are similar to human bone and tooth structure
The conversation of macroparticles into nanoparticles resulted in larger surface area increasing the reactivity of nanoparticles and hence its efficacy Nanoparticles have widespread use due to their superior properties and are being investigated extensively in recent years due to their advantagesNano -sized materials can enter dentinal tubules of 2 -3 µm in diameter easily occluding the dentinal tubules
Gluma Desensitizer is a combination of glutaraldehyde and HEMA Hydroxy Ethyl Methacrylate Glutaraldehyde causes amino acids and proteins to coagulate in dentinal tubules and is an effective disinfectant HEMA can be effective in sealing of dentinal tubules
Gluma does not interfere with dentin bonding systems but its glutaraldehyde component can damage the gingiva after long term exposure HEMA can cause contact dermatitis and it can actually perforate latex gloves and must be used with caution hence the use of rubber dam is advised in such cases
HEMA is soluble in water allowing it to penetrate deep into dentinal tubules however the effect is reversible and HEMA gradually loses its effect allowing the dentinal tubules to again became exposed
Hydroxyapatite powder is one such material that exhibits excellent bioactive properties and striking similarities to dental hard tissues can be achieved from two different sources Synthetic and natural biologic hydroxyapatiteHAP can be produced from Coral Seashells eggshells and also from body fluids
Recently the use of waste materials to synthesize HAP has received great response from many researchers across the world This idea gives an innovation to produce a new valuable product from the waste materials such as seashellSeashell consists of high source of calcium that can act as calcium precursor Some researcher found that the content of calcium carbonate CaCO3 in seashell is approximately between 98 and 99
The word seashell is often used to mean only the shell of a marine mollusk Using seashell as source of calcium carbonate CaCO3 to produce calcite nanoparticle is meaningful for both environmental protection and biomedical application Seashell is with the natural ceramic structure are similar to human bone and tooth structure
The conversation of macroparticles into nanoparticles resulted in larger surface area increasing the reactivity of nanoparticles and hence its efficacy Nanoparticles have widespread use due to their superior properties and are being investigated extensively in recent years due to their advantagesNano -sized materials can enter dentinal tubules of 2 -3 µm in diameter easily occluding the dentinal tubules
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None