Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06620666
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
None
First Post:
2024-09-18
Brief Title:
NEUROmuscular Training for Enhanced AGE Longevity
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Improvement of Biological and Functional Longevity Through Advanced Neuromuscular Training Protocols and Resources in Adulthood
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NEUROAGE
Brief Summary:
In recent years the research group on Prevention and Health in Exercise and Sport PHES has carried out numerous studies that have provided current and convincing evidence of the benefits of physical activity and exercise for chronic health but unfortunately it has also shown that if physical exercise is not properly prescribed it can impair health as well as accelerating the ageing process
The research proposal presented here aims to reveal some of the forms of physical exercise and resources for its application that may be most beneficial for peoples health thus trying to find reliable evidence that will increase healthy longevity and quality of life in society
Based on the above and taking into account that the possible beneficial adaptations for health are specific to the applied form of physical exercise and the equipment used during its development the PHES research group wishes to investigate the most appropriate strategies to ensure an active and positive ageing process
With these relevant findings the researchers can create specific action plans for prevention and promotion through physical exercise in order to improve both health and quality of life expectancy
The general objective of the project is to identify the most advanced methods and material resources with which to guarantee a beneficial process of active and healthy ageing with chronic training so that with these relevant findings concrete action plans can be created for prevention and promotion through physical exercise in order to improve both health and quality of life expectancy
The specific objectives are the following
To validate new specific safe and efficient tools to monitor the intensity of neuromuscular strength training activities in older adults
To analyze and compare the chronic effects of different cardiovascular and neuromuscular strength training modalities applied with different materials on cellular ageing body composition metabolic and immune profiles cognitive function motor function quality of life and well-being in older adults
To evaluate the efficacy of the use of dietary supplements to reduce or even stop the chronic adverse effects that different physical activity levels andor physical exercise programs can have on the oxidative and inflammatory profile body composition and metabolic profile muscle and DNA damage and physical performance in older adults
The research proposal presented here aims to reveal some of the forms of physical exercise and resources for its application that may be most beneficial for peoples health thus trying to find reliable evidence that will increase healthy longevity and quality of life in society
Based on the above and taking into account that the possible beneficial adaptations for health are specific to the applied form of physical exercise and the equipment used during its development the PHES research group wishes to investigate the most appropriate strategies to ensure an active and positive ageing process
With these relevant findings the researchers can create specific action plans for prevention and promotion through physical exercise in order to improve both health and quality of life expectancy
The general objective of the project is to identify the most advanced methods and material resources with which to guarantee a beneficial process of active and healthy ageing with chronic training so that with these relevant findings concrete action plans can be created for prevention and promotion through physical exercise in order to improve both health and quality of life expectancy
The specific objectives are the following
To validate new specific safe and efficient tools to monitor the intensity of neuromuscular strength training activities in older adults
To analyze and compare the chronic effects of different cardiovascular and neuromuscular strength training modalities applied with different materials on cellular ageing body composition metabolic and immune profiles cognitive function motor function quality of life and well-being in older adults
To evaluate the efficacy of the use of dietary supplements to reduce or even stop the chronic adverse effects that different physical activity levels andor physical exercise programs can have on the oxidative and inflammatory profile body composition and metabolic profile muscle and DNA damage and physical performance in older adults
Detailed Description:
The project presented here will consist of two stages
i Stage 1 Validation studies They consist in the development of validation of perceptual tools for pre-exercise quantification of the intensity of the training protocols with different training materials and methodologies The research in this first stage will take the form of a descriptive cross-sectional perceptual estimation studies Therefore this first stage of research will be performed prior to the application of the chronic studies and they will focus on validating resources for the proper control of intensity during the application of resistance training in elderly individuals by using measures of pre-exercise perceived exertion If these concepts are validated the researchers could state that will have created easily applicable and universal tools that will help to extend the appropriate use resistance training in older adults with highly accessible materials and conditions that can be applied internationally
ii Stage 2 Chronic studies They consist in the development of different intervention protocols to analyze the chronic effects of different regime of methodologies materials and food supplementation The research project presented here will continue in these second stages with prospective experimental studies of randomized intervention with older adults with pre- and post-treatment measurements The study population will be older adults belonging to a convenience sample who will participate voluntarily The study at this stage will consist of carrying out different intervention protocols over a period of 12-16 weeks
All the training programs of the chronic studies will start with familiarization sessions During the first familiarization sessions participants will be instructed on how to obtain the measure of the perceived exertion scale appropriate to the exercise intensity to be developed and also how to correctly perform the exercises of the training program As for the training plan in the different experimental groups participants will complete a list of exercises prescribed by the technicians which will be repeated in each session throughout the training plan Participants assigned to the sedentary control groups will be asked to continue with their normal diet and activities during the weeks of the study and will be prohibited from participating in any physical activity program or weight loss plan In contrast the experimental groups will perform a strength training program with the modality-specific method developed and with the type of material andor dietary supplement that corresponds to them according to the experimental design at a frequency of 2-3 days per week for 12-16 weeks The standard exercise session will have a protocolized structure with a warm-up a main exercise part and a cool-down
i Stage 1 Validation studies They consist in the development of validation of perceptual tools for pre-exercise quantification of the intensity of the training protocols with different training materials and methodologies The research in this first stage will take the form of a descriptive cross-sectional perceptual estimation studies Therefore this first stage of research will be performed prior to the application of the chronic studies and they will focus on validating resources for the proper control of intensity during the application of resistance training in elderly individuals by using measures of pre-exercise perceived exertion If these concepts are validated the researchers could state that will have created easily applicable and universal tools that will help to extend the appropriate use resistance training in older adults with highly accessible materials and conditions that can be applied internationally
ii Stage 2 Chronic studies They consist in the development of different intervention protocols to analyze the chronic effects of different regime of methodologies materials and food supplementation The research project presented here will continue in these second stages with prospective experimental studies of randomized intervention with older adults with pre- and post-treatment measurements The study population will be older adults belonging to a convenience sample who will participate voluntarily The study at this stage will consist of carrying out different intervention protocols over a period of 12-16 weeks
All the training programs of the chronic studies will start with familiarization sessions During the first familiarization sessions participants will be instructed on how to obtain the measure of the perceived exertion scale appropriate to the exercise intensity to be developed and also how to correctly perform the exercises of the training program As for the training plan in the different experimental groups participants will complete a list of exercises prescribed by the technicians which will be repeated in each session throughout the training plan Participants assigned to the sedentary control groups will be asked to continue with their normal diet and activities during the weeks of the study and will be prohibited from participating in any physical activity program or weight loss plan In contrast the experimental groups will perform a strength training program with the modality-specific method developed and with the type of material andor dietary supplement that corresponds to them according to the experimental design at a frequency of 2-3 days per week for 12-16 weeks The standard exercise session will have a protocolized structure with a warm-up a main exercise part and a cool-down
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None