Ignite Creation Date:
2024-05-05 @ 7:11 PM
Last Modification Date:
2024-10-26 @ 9:45 AM
Study NCT ID:
NCT00627172
Status:
COMPLETED
Last Update Posted:
2008-08-11
First Post:
2008-02-20
Brief Title:
Combined Use of Coronary MDCTA Coronary Doppler Ultrasonography and PET Perfusion in Diagnosing Coronary Artery Disease
Sponsor:
University of Turku
Organization:
University of Turku
Study Overview
Official Title:
Combined Use of Coronary MDCTA Coronary Doppler Ultrasonography and PET Perfusion in Diagnosis of Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2008-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PECTUS
Brief Summary:
Multislice CT angiography is a novel but already established and widely used in diagnosing coronary artery disease CAD It is very reliable in ruling out hemodynamically significant narrowings in coronary arteries Negative predictive value However it may overestimate the severity of the stenoses in up to 30 of the coronary artery lesions positive predictive value 70 However when coupled with a functional or flow-sensitive diagnostic test such as PET perfusion or coronary doppler ultrasonography one can assume that even the PPV may be as high as 95 Despite this assumption theres no scientific evidence to support use of such hybrid multi-modality tests at present
The investigators hypothesis is that improving the diagnostic accuracy of non-invasive diagnosis of coronary artery disease will decrease the proportion of patients that need catheter angiographies The avoidance of these unnecessary invasive procedures will improve patients quality of life and may even redirect health care resources in a more efficient way
The investigators hypothesis is that improving the diagnostic accuracy of non-invasive diagnosis of coronary artery disease will decrease the proportion of patients that need catheter angiographies The avoidance of these unnecessary invasive procedures will improve patients quality of life and may even redirect health care resources in a more efficient way
Detailed Description:
Coronary MDCTA multi-detector CT angiography is a novel but already established and widespread diagnostic method to diagnose coronary artery disease When performed with a 64-detector slice CT its strength is an excellent negative predictive value NPV 98 Specificity 86 is good but the positive predictive value PPV is only moderate 70 This is due to the ability of MDCTA to detect even minor vessel wall changes before they are functionally significant and the tendency of CT to overestimate the volume of dense calcifications However when coupled with a functional or flow-sensitive diagnostic test such as PET perfusion or coronary doppler ultrasonography one can assume that even the PPV may be as high as 95 Despite this assumption theres no scientific evidence to support use of such hybrid multi-modality tests at present
Our hypothesis is that improving the diagnostic accuracy of non-invasive diagnosis of coronary artery disease will decrease the proportion of patients that need catheter angiographies The avoidance of these unnecessary invasive procedures will improve patients quality of life and may even redirect health care resources in a more efficient way
Our hypothesis is that improving the diagnostic accuracy of non-invasive diagnosis of coronary artery disease will decrease the proportion of patients that need catheter angiographies The avoidance of these unnecessary invasive procedures will improve patients quality of life and may even redirect health care resources in a more efficient way
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None