Ignite Creation Date:
2024-10-26 @ 3:41 PM
Last Modification Date:
2024-10-26 @ 3:41 PM
Study NCT ID:
NCT06616428
Status:
COMPLETED
Last Update Posted:
None
First Post:
2024-09-22
Brief Title:
Acute Exercise Effects on Arterial Stiffness and Cardiovagal Modulation in Adults
Sponsor:
None
Organization:
None
Study Overview
Official Title:
Acute Effects of Commercial Group Exercise Classes on Arterial Stiffness and Cardiovagal Modulation in Healthy Young and Middle-aged Adults an Ecological Valid Model
Status:
COMPLETED
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PUMPING ARTERY
Brief Summary:
Background and Gap
The physiological importance of large artery distensibility in cardiovascular function is well-established Stiffening of central arteries leads to elevated systolic blood pressure SBP increased left ventricular afterload and altered coronary artery perfusion These changes can elevate cardiovascular disease risk and all-cause mortality Cardiac autonomic function including heart rate recovery HRR and heart rate variability HRV is closely linked to blood pressure regulation Reductions in HRR and HRV are predictive of cardiovascular mortality The dynamic regulation of arterial stiffness and autonomic function post-exercise is crucial for both health and performance outcomes Exercise particularly aerobic has been shown to reduce arterial stiffness but evidence across different exercise modalities is limited especially for group fitness classes These classes are a common method for achieving cardiovascular fitness but their acute effects on arterial stiffness and autonomic function remain understudied
Study Type Parallel Group Crossover Randomised Trial Primary Purpose To assess and compare the acute effects of three commercially available group exercise classes on arterial stiffness and cardiovagal modulation in healthy young and middle-aged adults
Study Population Healthy adults aged 18-60 years
Main Question
How does age influence post-exercise recovery patterns in arterial stiffness and cardiovagal modulation following different group fitness classes
Comparison Group Researchers compared arterial stiffness and autonomic function responses across three group fitness classes in young and older adults
Participant Tasks
Attend a 60-minute group exercise class
Undergo measurements of arterial stiffness and autonomic function before and after 3 group fitness classes
The physiological importance of large artery distensibility in cardiovascular function is well-established Stiffening of central arteries leads to elevated systolic blood pressure SBP increased left ventricular afterload and altered coronary artery perfusion These changes can elevate cardiovascular disease risk and all-cause mortality Cardiac autonomic function including heart rate recovery HRR and heart rate variability HRV is closely linked to blood pressure regulation Reductions in HRR and HRV are predictive of cardiovascular mortality The dynamic regulation of arterial stiffness and autonomic function post-exercise is crucial for both health and performance outcomes Exercise particularly aerobic has been shown to reduce arterial stiffness but evidence across different exercise modalities is limited especially for group fitness classes These classes are a common method for achieving cardiovascular fitness but their acute effects on arterial stiffness and autonomic function remain understudied
Study Type Parallel Group Crossover Randomised Trial Primary Purpose To assess and compare the acute effects of three commercially available group exercise classes on arterial stiffness and cardiovagal modulation in healthy young and middle-aged adults
Study Population Healthy adults aged 18-60 years
Main Question
How does age influence post-exercise recovery patterns in arterial stiffness and cardiovagal modulation following different group fitness classes
Comparison Group Researchers compared arterial stiffness and autonomic function responses across three group fitness classes in young and older adults
Participant Tasks
Attend a 60-minute group exercise class
Undergo measurements of arterial stiffness and autonomic function before and after 3 group fitness classes
Detailed Description:
All participants were randomly assigned to 1 of 4 experimental conditions using a randomized block scheme httpswwwrandomizerorg Participants completed 4 separate intervention sessions each consisting of an initial rest a group fitness class of either indoor cycling resistance training combined exercise training or no exercise CON followed by a recovery period A minimum of 72 hours between sessions was ensured Body composition and cardiorespiratory fitness for each participant were evaluated before and after the CON session respectively
Each session began with 20 minutes of supine rest on a cushioned examination table with resting energy expenditure REE measured by indirect calorimetry K5 Cosmed Rome Italy and heart rate HR and blood pressure BP recorded continuously using digital plethysmography Finapres NOVA Finapres Medical Systems Amsterdam The Netherlands This was followed by 1 Regional assessments of PWV and pulse wave analysis of the carotid brachial femoral and distal arteries on the right side of the body using applanation tonometry Complior 20 Alam Medical Saint Quentin Fallavier France and 2 Assessment of heart rate variability HRV and baroreflex sensitivity BRS indices using the Finapres NOVA 5 ECG lead module Following these assessments participants engaged in a 45-minute group fitness class while activity energy expenditure AEE was continuously measured by indirect calorimetry K5 Cosmed Rome Italy In the CON session participants remained comfortably seated for 45 minutes maintaining a good posture After each group fitness class participants immediately returned to the examination table and recovered in the supine position for 30 minutes during which local and regional stiffness HRV and baroreflex sensitivity BRS were re-evaluated at 10- 20- and 30-minute intervals during recovery and compared to those at rest Participants were blinded to the order of the experimental interventions until arrival at the laboratory All sessions were conducted in the morning to minimize potential diurnal variation Participants were also instructed not to ingest any food or drink except water 4 hours before the sessions and to avoid alcohol caffeine and exercise for at least 24 hours preceding each session
Based on a medium effect size of 0154 derived from published changes in aortic PWV within-between modes of exercise 23 an a priori power analysis suggested that 22 participants were required 11 per group to detect significant differences within-between groups conditions and time points 1-β 80 α 005
Each session began with 20 minutes of supine rest on a cushioned examination table with resting energy expenditure REE measured by indirect calorimetry K5 Cosmed Rome Italy and heart rate HR and blood pressure BP recorded continuously using digital plethysmography Finapres NOVA Finapres Medical Systems Amsterdam The Netherlands This was followed by 1 Regional assessments of PWV and pulse wave analysis of the carotid brachial femoral and distal arteries on the right side of the body using applanation tonometry Complior 20 Alam Medical Saint Quentin Fallavier France and 2 Assessment of heart rate variability HRV and baroreflex sensitivity BRS indices using the Finapres NOVA 5 ECG lead module Following these assessments participants engaged in a 45-minute group fitness class while activity energy expenditure AEE was continuously measured by indirect calorimetry K5 Cosmed Rome Italy In the CON session participants remained comfortably seated for 45 minutes maintaining a good posture After each group fitness class participants immediately returned to the examination table and recovered in the supine position for 30 minutes during which local and regional stiffness HRV and baroreflex sensitivity BRS were re-evaluated at 10- 20- and 30-minute intervals during recovery and compared to those at rest Participants were blinded to the order of the experimental interventions until arrival at the laboratory All sessions were conducted in the morning to minimize potential diurnal variation Participants were also instructed not to ingest any food or drink except water 4 hours before the sessions and to avoid alcohol caffeine and exercise for at least 24 hours preceding each session
Based on a medium effect size of 0154 derived from published changes in aortic PWV within-between modes of exercise 23 an a priori power analysis suggested that 22 participants were required 11 per group to detect significant differences within-between groups conditions and time points 1-β 80 α 005
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None